Thymic Stromal Lymphopoietin Protein (TSLP) (His tag)

Catalog No. ABIN7321026

Product Details

Target: Thymic Stromal Lymphopoietin (TSLP)

Protein Type: Recombinant

Biological Activity: Active

Origin: Cynomolgus

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Thymic Stromal Lymphopoietin protein is labelled with His tag.

Purpose: Recombinant Cynomolgus Thymic Stromal Lymphopoietin/TSLP (C-6His)

Sequence: Tyr29-Gln159(Glu37Gln)

Characteristics: Recombinant Cynomolgus Thymic Stromal Lymphopoietin is produced by our E.coli expression system and the target gene encoding Tyr29-Gln159(Glu37Gln) is expressed with a 6His tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Mouse TSLPR-Fc(Cat#PKSM041158) at 10μg/ml (100 μl/well) can bind Biotinylated Cynomolgus TSLP-His(Cat#PKSQ050102). The ED50 of Cynomolgus TSLP-His(Cat#PKSQ050102)is 3.2ug/ml .

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 500 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Thymic Stromal Lymphopoietin (TSLP)

Alternative Name: Thymic Stromal Lymphopoietin/TSLP (TSLP Products)

Synonyms: TSLP Protein, thymic stromal lymphopoietin Protein, TSLP Protein, Tslp Protein

Background:

Background: Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family, contains 140 amino acids. It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells. TSLP induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. It can induce allergic inflammation by directly activating mast cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells. These cells are located in regions where TSLP activity is required.

Synonym: Thymic stromal lymphopoietin, Thymic stroma-derived lymphopoietin, TSLP 

Molecular Weight: 16.2 kDa

NCBI Accession: XP_005557555