Thymic Stromal Lymphopoietin Protein (TSLP) (His tag)

Catalog No. ABIN7198241

Product Details

Target: Thymic Stromal Lymphopoietin (TSLP)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Thymic Stromal Lymphopoietin protein is labelled with His tag.

Purpose: Recombinant Mouse TSLP Protein (His Tag)(Active)

Sequence: Met 1-Glu 140

Characteristics: A DNA sequence encoding the mouse TSLP (Q9JIE6) (Met 1-Glu 140) was expressed, with a C-terminal polyhistidine tag.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind human IL7RA-his in functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Thymic Stromal Lymphopoietin (TSLP)

Alternative Name: TSLP (TSLP Products)

Synonyms: TSLP Protein, thymic stromal lymphopoietin Protein, TSLP Protein, Tslp Protein

Background:

Background: Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation.  Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.

Synonym: Thymic stromal lymphopoietin;Thymic stroma-derived lymphopoietin;Tslp;TSLP

Molecular Weight: 15.4 kDa

UniProt: Q9JIE6