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The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Additionally we are shipping Tousled-Like Kinase 1 Antibodies (134) and Tousled-Like Kinase 1 Kits (2) and many more products for this protein.
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Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1 (show NEK1 Proteins)-T141A mutant impaired ATR (show ANTXR1 Proteins) and Chk1 (show CHEK1 Proteins) activation, indicating the existence of a TLK1>NEK1 (show NEK1 Proteins)>ATR (show ANTXR1 Proteins)>Chk1 (show CHEK1 Proteins) pathway. Indeed, overexpression of the NEK1 (show NEK1 Proteins)-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.
Our results suggest that GA-mediated transient modulation of TLK1 activity promotes DNA repair and suppresses radiation cytoxicity in salivary gland cells.
TLK1B mediated phosphorylation of Rad9 (show RAD9A Proteins) regulates its nuclear/cytoplasmic localization and cell cycle checkpoint
Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a (show ASF1A Proteins) and Asf1b (show ASF1B Proteins) function.
Tousled-like kinase-dependent phosphorylation of Rad9 (show RAD9A Proteins) plays a role in cell cycle progression and G2/M checkpoint exit.
Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.
Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.
ASF1 (show SRSF1 Proteins) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (show SRSF1 Proteins) and hASF1a (show ASF1A Proteins) by TLK (show TLK2 Proteins) kinases.
we show that Chk1 (show CHEK1 Proteins) is essential for the suppression of TLK (show TLK2 Proteins) activity after replication block, but that ATR (show ANTXR1 Proteins), Chk2 (show CHEK2 Proteins) and BRCA1 are dispensable for TLK (show TLK2 Proteins) suppression.
Both eIF4E (show EIF4E Proteins) and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E (show EIF4E2 Proteins) overexpression.
TLK1 and TLK2 (show TLK2 Proteins) have largely redundant roles in genome maintenance.
TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
SNARE protein kinase SNAK
, serine threonine protein kinase
, serine/threonine-protein kinase tousled-like 1
, pKU-beta protein kinase
, serine/threonine-protein kinase tousled-like 1-B
, tousled-like kinase 1
, tousled-like kinase 1-B
, LOW QUALITY PROTEIN: serine/threonine-protein kinase tousled-like 1