Tousled-Like Kinase 1 Proteins (TLK1)

The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Additionally we are shipping Tousled-Like Kinase 1 Antibodies (133) and Tousled-Like Kinase 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TLK1 9874 Q9UKI8
TLK1 228012 Q8C0V0
Rat TLK1 TLK1 311118  
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Top Tousled-Like Kinase 1 Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Baculovirus infected Insect Cells Human GST tag,His tag 50 μg 14 to 16 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Insect Cells Human GST tag 5 μg 11 to 12 Days
Insect Cells Human GST tag   10 μg 3 to 4 Days

TLK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Tousled-Like Kinase 1 (TLK1) Interaction Partners

Human Tousled-Like Kinase 1 (TLK1) interaction partners

  1. Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR and Chk1 activation, indicating the existence of a TLK1>NEK1>ATR>Chk1 pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint.

  2. Our results suggest that GA-mediated transient modulation of TLK1 activity promotes DNA repair and suppresses radiation cytoxicity in salivary gland cells.

  3. TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint

  4. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function.

  5. Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.

  6. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.

  7. Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.

  8. Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.

  9. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.

  10. we show that Chk1 is essential for the suppression of TLK activity after replication block, but that ATR, Chk2 and BRCA1 are dispensable for TLK suppression.

  11. Both eIF4E and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E overexpression.

  12. In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68.

  13. TLK1B promotes the repair of double strand breaks, likely as a consequence of a change in chromatin remodeling capacity that must precede the assembly of repair complexes at the sites of damage

  14. Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 triggering DNA repair.

  15. Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis.

Mouse (Murine) Tousled-Like Kinase 1 (TLK1) interaction partners

  1. our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.

  2. TLK1 and TLK2 have largely redundant roles in genome maintenance.

  3. present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.

Caenorhabditis elegans (C. elegans) Tousled-Like Kinase 1 (TLK1) interaction partners

  1. TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.

  2. Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.

Tousled-Like Kinase 1 (TLK1) Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tousled-Like Kinase 1 Proteins (TLK1)

  • tousled like kinase 1 (TLK1)
  • tousled-like kinase 1 (Tlk1)
  • tousled-like kinase 1b (tlk1b)
  • tousled like kinase 1 like (TLK1L)
  • tousled-like kinase 1 (TLK1)
  • serine/threonine-protein kinase TOUSLED (LOC542181)
  • tousled-like kinase 1a (tlk1a)
  • tousled like kinase 1 (tlk1)
  • Serine/threonine-protein kinase tousled-like 1 (tlk-1)
  • tousled like kinase 1 (Tlk1)
  • 4930545J15Rik protein
  • DKFZp459L163 protein
  • fb76h12 protein
  • fe11e12 protein
  • PKU-beta protein
  • si:dkey-88m1.1 protein
  • si:dkey-251e16.4 protein
  • TLK1 protein
  • wu:fb76h12 protein
  • wu:fe11e12 protein

Protein level used designations for Tousled-Like Kinase 1 Proteins (TLK1)

SNARE protein kinase SNAK , serine threonine protein kinase , serine/threonine-protein kinase tousled-like 1 , pKU-beta protein kinase , serine/threonine-protein kinase tousled-like 1-B , tousled-like kinase 1 , tousled-like kinase 1-B , LOW QUALITY PROTEIN: serine/threonine-protein kinase tousled-like 1

9874 Homo sapiens
228012 Mus musculus
311118 Rattus norvegicus
326734 Danio rerio
429024 Gallus gallus
459729 Pan troglodytes
478795 Canis lupus familiaris
537517 Bos taurus
542181 Zea mays
557765 Danio rerio
100024843 Monodelphis domestica
100052963 Equus caballus
100144941 Xenopus (Silurana) tropicalis
100157412 Sus scrofa
100174001 Pongo abelii
100345497 Oryctolagus cuniculus
100554902 Anolis carolinensis
100591136 Nomascus leucogenys
176369 Caenorhabditis elegans
100734588 Cavia porcellus
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