anti-Tyrosinase-Related Protein 1 (TYRP1) Antibodies

Human Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. catalytic pathway starts with the tyrosinase HsTYR and two tyrosinase-related proteins HsTYRP1 and HsTYRP2. All three enzymes have the same active site but the latter two contain two zinc ions instead of copper ions

2. The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype.

3. TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA.

4. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16.

5. DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.

6. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.

7. Mutation in TYRP1 is associated with oculocutaneous albinism.

8. Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity

9. These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.

10. These data indicate that galectin-3 is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.

11. p53 regulation by TRP2 is not pervasive in melanoma.

12. Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III.

13. in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation.

14. High TYRP1/S100B mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome.

15. We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1.

16. The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.

17. identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance

18. By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR and TYRP1.

19. We used the first ranked gene, tyrosinase-related protein 1 (TYRP1), further measured its expression in the validation population by real-time PCR and found it to be significantly correlated with distant metastasis-free survival.

20. two novel mutations in TYRP1 gene in two Chinese patients with oculocutaneous albinism type 3

Zebrafish Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype

2. The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE cells and the NCDM in zebrafish.

Cow (Bovine) Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.

Pig (Porcine) Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.

Rabbit Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR), as well as genes with unknown functions.

2. A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.

Mouse (Murine) Tyrosinase-Related Protein 1 (TYRP1) interaction partners

1. Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.

2. the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells

3. Studied upregulation by Kaliziri extract of tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.

4. The SNARE machinery composed of VAMP7 on Tyrp1-containing vesicles and syntaxin-3 and SNAP23 on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.

5. Addition of a TRP-1-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.

6. analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage

7. GILT-deficient mice have an increase in TRP1-specific regulatory T (Treg) cells compared with TRP1-deficient mice, and depletion of Treg cells partially restores the ability of GILT-deficient TRP1-specific CD4(+) T cells to induce vitiligo.

8. The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.

9. DNA vaccination with a melanoma-shared antigen Trp1, combined with systemic TGF-beta blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.

10. both the Rab32/38 binding activity and VAMP7 binding activity of Varp are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 by the VPS9 domain is not necessary for Tyrp1 trafficking

11. Tyrosinase-related protein 1 (Tyrp1) displayed enriched expression in the dorsal root ganglia, an inactivating mutation in the A/J mouse strain, and a null mutant found to be more resistant to thermal nociception compared to its wild-type counterpart.

12. this study suggests that DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin, which highlights the important role of Dct in the regulation of DHICA-mediated antioxidation.

13. We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1

14. used sequence polymorphisms to finely map the deletion breakpoints and identify strong candidate genes for the known phenotypes

15. The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE.

16. the role of Tyrp1 mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear

17. these data demonstrate that Tyrp1 interacts directly with Tyrosinase in vivo, which may regulate the stability and trafficking of melanogenic enzymes and thus pigment synthesis.

18. NZG/Kgm mouse has two recessive pigmentation variant genes (oca2(p) and tyrp-1(b)) and that the tyrp-1(b) gene locus associates with large body size.

19. Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes.

20. Data demonstrate that endogenous tyrosinase-related protein-1 expression alters the functionality of the autoreactive T cell repertoire.