Tyrosinase-Related Protein 1 antibody (Middle Region)

Catalog No. ABIN2781815

This Rabbit Polyclonal antibody specifically detects Tyrosinase-Related Protein 1 in IHC and WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Goat, Horse, Rabbit, Sheep, Cow, Guinea Pig and Zebrafish (Danio rerio).It has been mentioned in 1 publication

Quick Overview for Tyrosinase-Related Protein 1 antibody (Middle Region) (ABIN2781815)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human, Mouse, Rat, Dog, Goat, Horse, Rabbit, Sheep, Cow, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Binding Specificity: Middle Region

Purpose: TYRP1 Antibody - middle region

Sequence: NDPIFVLLHT FTDAVFDEWL RRYNADISTF PLENAPIGHN RQYNMVPFWP

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against TYRP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TYRP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44315-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Tyrosinase-Related Protein 1 antibody (ABIN2781815)

Horibe, Satoh, Shiota, Kumagai, Horike, Takemori, Uesato, Sugie, Obata, Kawahara, Nagaoka: "Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells." in: Journal of natural medicines, Vol. 67, Issue 4, pp. 705-10, (2013) (PubMed).

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: TYRP1

Background:

Background Information: TYRP1 catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. It may regulate or influence the type of melanin synthesized.

Gene Name: Tyrosinase-related protein 1

Alternative Symbols: TRP, CAS2, CATB, GP75, OCA3, TRP1, TYRP, b-PROTEIN

Protein Name: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Molecular Weight: 61 kDa

Gene ID: 7306

NCBI Accession: NP_000541

UniProt: P17643