anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Antibodies

May act as a negative regulator of cell growth..

list all antibodies Gene Name GeneID UniProt
Anti-Human UHRF1 UHRF1 29128 Q96T88
Anti-Mouse UHRF1 UHRF1 18140 Q8VDF2
Anti-Rat UHRF1 UHRF1 316129 Q7TPK1
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Top anti-UHRF1 Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UHRF1 Antibody  Positive Control: Lane 1: 60ug HCT116 lysate Lane 2: 60ug HCT116 lysate + siRNA  Primary Antibody Dilution :  1:1000 Secondary Antibody : Anti rabbit-HRP  Secondry Antibody Dilution :  1:5,000 Submitted by: Chinweike Ukomadu, Brigham and Women's Hospital, Boston WB Suggested Anti-UHRF1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  UHRF1  Sample Type:  HepG2 Whole cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of UHRF1 expression in MCF-7 whole cell lysates (lane 1) and U2OS whole cell lysates (lane 2). UHRF1 at 90KD was detected using rabbit anti- UHRF1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of UHRF1 expression in HeLa (A), HCT116 (B), HEK293 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to UHRF1 on HeLa cell (antibody concentration 10 µg/mL). UHRF1 monoclonal antibody (M01), clone 3A11 Western Blot analysis of UHRF1 expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Detection of Human NP95//UHRF1 by Western Blot and Immunoprecipitation.  Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells.  Antibodies: Affinity purified rabbit anti-NP95//UHRF1 antibody ABIN261674 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  NP95//UHRF1 was also immunoprecipitated by another rabbit anti-NP95//UHRF1 antibody, which recognizes a downstream epitope.   Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Immunohistochemistry-Paraffin: UHRF1 Antibody [ABIN2616747] - FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-NP95/UHRF1 used at a dilution of 1:200 (1ug/ml). Detection: DAB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Mouse Un-conjugated ICC, IF, IP, IHC, WB Uhrf1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with Uhrf1 antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated ChIP, IF, IP, IHC, WB 100 μg Log in to see 2 to 3 Days
$335.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Immunohistochemical analysis of paraffin-embedded BT483 xenograft, using UHRF1, antibody at 1:250 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details

Top referenced anti-UHRF1 Antibodies

  1. Human Monoclonal UHRF1 Primary Antibody for ICC, IF - ABIN2668962 : Hopfner, Mousli, Jeltsch, Voulgaris, Lutz, Marin, Bellocq, Oudet, Bronner: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. in Cancer research 2000 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal UHRF1 Primary Antibody for IF, ELISA - ABIN565416 : Mistry, Gibson, Yun, Sarras, Tamblyn, McPherson: Interplay between Np95 and Eme1 in the DNA damage response. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal UHRF1 Primary Antibody for ICC, IF - ABIN261674 : Ma, Chen, Guo, Wang, Sowa, Zheng, Hu, Zeng, Guo, Diao, Lan, Harper, Shi, Xu, Shi: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against UHRF1 Interaction Partners

Human Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. The emodininduced downregulation of UHRF1 led to an increase in the level of DNA methyltransferase 3A (show DNMT3A Antibodies).

  2. Findings confirmed that UHRF1 is a gene driver in medulloblastoma (MB) and, revealed that UHRF1 is in a modulation axis downstream of miR (show MLXIP Antibodies)-378. Its promoter region is targeted by miR (show MLXIP Antibodies)-378 which negatively regulates its expression in MB cells.

  3. The induced expression of RIP3 (show RIPK3 Antibodies) by UHRF1 RNAi depends on the presence of Sp1 (show PSG1 Antibodies). Remarkably, the ectopic expression of RIP3 (show RIPK3 Antibodies) in RIP3 (show RIPK3 Antibodies)-null cancer cells results in a decrease in tumor growth in mice. Therefore, our findings offer insights into RIP3 (show RIPK3 Antibodies) expression control in cancer cells and suggest an inhibitory effect of RIP3 (show RIPK3 Antibodies) on tumorigenesis.

  4. UHRF1 controls both CDH1 (show CDH1 Antibodies) and antisense-directed non coding RNA RCDH1-AS by directly binding this bidirectional promoter region.

  5. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 (show DNMT1 Antibodies) axis has been demonstrated for humans and mice.

  6. These results suggest that tumor-promoting functions of UHRF1 in retinoblastoma are largely independent of its role in DNA methylation (show HELLS Antibodies).

  7. UHRF1 is a key epigenetic regulator of DNA methylation (show HELLS Antibodies) in esophageal squamous cell carcinoma and might be a potential target for cancer treatment

  8. Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma.

  9. Results find the overexpression of the anti-apoptotic UHRF1 to coordinate the epigenetic silencing of several tumor suppressor genes in many human haematological and solid cancers causing apoptosis inhibition. [review]

  10. our present data demonstrated that both strands of miR (show MLXIP Antibodies)-145 (miR (show MLXIP Antibodies)-145-5p: guide-strand and miR (show MLXIP Antibodies)-145-3p: passenger-strand) play pivotal roles in bladder cancer cells by regulating UHRF1

Mouse (Murine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 (show DNMT1 Antibodies) axis has been demonstrated for humans and mice.

  2. These results indicate that Uhrf1 governs cell type-specific transcriptional regulation by controlling the genome-wide DNA methylation (show HELLS Antibodies) status and regulating consequent cell differentiation and skeletal maturation.

  3. UHRF1 ubiquitinates PAF15 at Lys (show LYZ Antibodies) 15 and Lys (show LYZ Antibodies) 24 and promotes its binding to PCNA (show PCNA Antibodies) during late S-phase

  4. Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.

  5. SETDB1 (show SETDB1 Antibodies) maintains silencing of intracisternal A particle, but in the absence of DNMT1 (show DNMT1 Antibodies), prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 Antibodies)-dependent H3K9me3 deposition.

  6. deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP (show ALPI Antibodies)) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine

  7. Our results provide insights into the molecular basis of DNMT1 (show DNMT1 Antibodies) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS Antibodies) in pluripotent and differentiating cells

  8. results identify UHRF1 as a novel HSP90 (show HSP90 Antibodies) client protein and shed light on the regulation of UHRF1 stability and function.

  9. Uhrf1 regulation of the Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) signaling pathway is required for invariant natural killer T cell development.

  10. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (show HIST1H3B Antibodies) recognition.

Zebrafish Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Dnmt1 (show DNMT1 Antibodies) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.

  3. an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (show CDK2 Antibodies)/cyclin A2 (show CCNA2 Antibodies) during early vertebrate development

  4. These data provide the first evidence that Uhrf1 and Dnmt1 (show DNMT1 Antibodies) function is required for vertebrate lens development and maintenance.

  5. uhrf1 is required for physiologic liver growth in both embryos and adults

Pig (Porcine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

UHRF1 Antigen Profile

Protein Summary

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with UHRF1

  • ubiquitin like with PHD and ring finger domains 1 (UHRF1) antibody
  • ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1) antibody
  • ubiquitin-like with PHD and ring finger domains 1 (Uhrf1) antibody
  • ubiquitin-like with PHD and ring finger domains 1 (uhrf1) antibody
  • ubiquitin like with PHD and ring finger domains 1 (Uhrf1) antibody
  • AL022808 antibody
  • fb97f09 antibody
  • hNP95 antibody
  • hUHRF1 antibody
  • ICBP90 antibody
  • NP95 antibody
  • RNF106 antibody
  • UHRF1 antibody
  • wu:fb97f09 antibody
  • zgc:63539 antibody

Protein level used designations for UHRF1

E3 ubiquitin-protein ligase UHRF1 , RING finger protein 106 , huNp95 , inverted CCAAT box-binding protein of 90 kDa , nuclear protein 95 , nuclear zinc finger protein Np95 , transcription factor ICBP90 , ubiquitin-like PHD and RING finger domain-containing protein 1 , ubiquitin-like, containing PHD and RING finger domains, 1 , ubiquitin-like-containing PHD and RING finger domains protein 1 , mUhrf1 , liver regeneration-related protein LRRG126 , ubiquitin-like with PHD and ring finger domains 1

GENE ID SPECIES
29128 Homo sapiens
18140 Mus musculus
316129 Rattus norvegicus
406350 Danio rerio
420154 Gallus gallus
455613 Pan troglodytes
530411 Bos taurus
611463 Canis lupus familiaris
100062347 Equus caballus
100511003 Sus scrofa
100719542 Cavia porcellus
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