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May act as a negative regulator of cell growth..
Showing 10 out of 115 products:
Human Monoclonal UHRF1 Primary Antibody for ICC, IF - ABIN2668962
Hopfner, Mousli, Jeltsch, Voulgaris, Lutz, Marin, Bellocq, Oudet, Bronner: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. in Cancer research 2000
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Human Monoclonal UHRF1 Primary Antibody for IF, ELISA - ABIN565416
Mistry, Gibson, Yun, Sarras, Tamblyn, McPherson: Interplay between Np95 and Eme1 in the DNA damage response. in Biochemical and biophysical research communications 2008
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Human Polyclonal UHRF1 Primary Antibody for ICC, IF - ABIN261674
Ma, Chen, Guo, Wang, Sowa, Zheng, Hu, Zeng, Guo, Diao, Lan, Harper, Shi, Xu, Shi: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. in Proceedings of the National Academy of Sciences of the United States of America 2012
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The emodininduced downregulation of UHRF1 led to an increase in the level of DNA methyltransferase 3A (show DNMT3A Antibodies).
Findings confirmed that UHRF1 is a gene driver in medulloblastoma (MB) and, revealed that UHRF1 is in a modulation axis downstream of miR (show MLXIP Antibodies)-378. Its promoter region is targeted by miR (show MLXIP Antibodies)-378 which negatively regulates its expression in MB cells.
The induced expression of RIP3 (show RIPK3 Antibodies) by UHRF1 RNAi depends on the presence of Sp1 (show PSG1 Antibodies). Remarkably, the ectopic expression of RIP3 (show RIPK3 Antibodies) in RIP3 (show RIPK3 Antibodies)-null cancer cells results in a decrease in tumor growth in mice. Therefore, our findings offer insights into RIP3 (show RIPK3 Antibodies) expression control in cancer cells and suggest an inhibitory effect of RIP3 (show RIPK3 Antibodies) on tumorigenesis.
UHRF1 controls both CDH1 (show CDH1 Antibodies) and antisense-directed non coding RNA RCDH1-AS by directly binding this bidirectional promoter region.
Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 (show DNMT1 Antibodies) axis has been demonstrated for humans and mice.
These results suggest that tumor-promoting functions of UHRF1 in retinoblastoma are largely independent of its role in DNA methylation (show HELLS Antibodies).
UHRF1 is a key epigenetic regulator of DNA methylation (show HELLS Antibodies) in esophageal squamous cell carcinoma and might be a potential target for cancer treatment
Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma.
Results find the overexpression of the anti-apoptotic UHRF1 to coordinate the epigenetic silencing of several tumor suppressor genes in many human haematological and solid cancers causing apoptosis inhibition. [review]
our present data demonstrated that both strands of miR (show MLXIP Antibodies)-145 (miR (show MLXIP Antibodies)-145-5p: guide-strand and miR (show MLXIP Antibodies)-145-3p: passenger-strand) play pivotal roles in bladder cancer cells by regulating UHRF1
These results indicate that Uhrf1 governs cell type-specific transcriptional regulation by controlling the genome-wide DNA methylation (show HELLS Antibodies) status and regulating consequent cell differentiation and skeletal maturation.
UHRF1 ubiquitinates PAF15 at Lys (show LYZ Antibodies) 15 and Lys (show LYZ Antibodies) 24 and promotes its binding to PCNA (show PCNA Antibodies) during late S-phase
Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.
SETDB1 (show SETDB1 Antibodies) maintains silencing of intracisternal A particle, but in the absence of DNMT1 (show DNMT1 Antibodies), prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 Antibodies)-dependent H3K9me3 deposition.
deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP (show ALPI Antibodies)) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine
Our results provide insights into the molecular basis of DNMT1 (show DNMT1 Antibodies) dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS Antibodies) in pluripotent and differentiating cells
results identify UHRF1 as a novel HSP90 (show HSP90 Antibodies) client protein and shed light on the regulation of UHRF1 stability and function.
Uhrf1 regulation of the Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) signaling pathway is required for invariant natural killer T cell development.
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone (show HIST1H3B Antibodies) recognition.
Dnmt1 (show DNMT1 Antibodies) stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.
an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2 (show CDK2 Antibodies)/cyclin A2 (show CCNA2 Antibodies) during early vertebrate development
These data provide the first evidence that Uhrf1 and Dnmt1 (show DNMT1 Antibodies) function is required for vertebrate lens development and maintenance.
uhrf1 is required for physiologic liver growth in both embryos and adults
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
E3 ubiquitin-protein ligase UHRF1
, RING finger protein 106
, inverted CCAAT box-binding protein of 90 kDa
, nuclear protein 95
, nuclear zinc finger protein Np95
, transcription factor ICBP90
, ubiquitin-like PHD and RING finger domain-containing protein 1
, ubiquitin-like, containing PHD and RING finger domains, 1
, ubiquitin-like-containing PHD and RING finger domains protein 1
, liver regeneration-related protein LRRG126
, ubiquitin-like with PHD and ring finger domains 1