anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) Antibodies

May act as a negative regulator of cell growth.. Additionally we are shipping UHRF1 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UHRF1 29128 Q96T88
UHRF1 18140 Q8VDF2
UHRF1 316129 Q7TPK1
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Top anti-UHRF1 Antibodies at

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UHRF1 Antibody  Positive Control: Lane 1: 60ug HCT116 lysate Lane 2: 60ug HCT116 lysate + siRNA  Primary Antibody Dilution :  1:1000 Secondary Antibody : Anti rabbit-HRP  Secondry Antibody Dilution :  1:5,000 Submitted by: Chinweike Ukomadu, Brigham and Women's Hospital, Boston WB Suggested Anti-UHRF1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Stomach 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  UHRF1  Sample Type:  HepG2 Whole cell lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of UHRF1 expression in MCF-7 whole cell lysates ( Lane 1) and U2OS whole cell lysates ( Lane 2). UHRF1 at 90KD was detected using rabbit anti- UHRF1 Antigen Affinity purified polyclonal antibody (Catalog # ) at0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
Human Rabbit Un-conjugated WB Western blot analysis of UHRF1 expression in HeLa (A), HCT116 (B), HEK293 (C) whole cell lysates. 200 μL 13 to 14 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated ChIP, IF, IP, IHC, WB 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Immunohistochemical analysis of paraffin-embedded BT483 xenograft, using UHRF1, antibody at 1:250 dilution. 100 μL 3 to 4 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
Human Mouse Un-conjugated IF, ELISA, WB Immunoperoxidase of monoclonal antibody to UHRF1 on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 3 ug/ml] UHRF1 monoclonal antibody (M01), clone 3A11 Western Blot analysis of UHRF1 expression in Hela S3 NE . 100 μg 11 to 12 Days
Human Mouse Un-conjugated ELISA, WB   100 μL Available

Top referenced anti-UHRF1 Antibodies

  1. Human Monoclonal UHRF1 Primary Antibody for IF, ELISA - ABIN565416 : Mistry, Gibson, Yun, Sarras, Tamblyn, McPherson: Interplay between Np95 and Eme1 in the DNA damage response. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal UHRF1 Primary Antibody for ICC, IF - ABIN261674 : Ma, Chen, Guo, Wang, Sowa, Zheng, Hu, Zeng, Guo, Diao, Lan, Harper, Shi, Xu, Shi: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal UHRF1 Primary Antibody for ICC, IF - ABIN2668962 : Hopfner, Mousli, Jeltsch, Voulgaris, Lutz, Marin, Bellocq, Oudet, Bronner: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. in Cancer research 2000 (PubMed)
    Show all 2 Pubmed References

More Antibodies against UHRF1 Interaction Partners

Human Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. These findings reveal that WDR79 is a novel UHRF1 regulator by maintaining UHRF1 stability.

  2. a novel mechanism by which FOXM1 controls cancer stem cells and taxane resistance through a UHRF1-mediated signaling pathway

  3. hese findings establish UBE2L6 as a novel target of UHRF1 that regulates the apoptosis function of UHRF1.

  4. SET7-mediated UHRF1 methylation is also shown to be essential for cell viability against DNA damage. Our data revealed the regulatory mechanism underlying the UHRF1 methylation status by SET7 and LSD1 in double-strand break repair pathway

  5. UHRF1-mediated XRCC4 upregulation under pathophysiological conditions triggered by RB1 gene inactivation may confer protection against endogenous DNA damages that arise during retinoblastoma development.

  6. Uncoupling of UHRF2 from the DNA methylation maintenance program is linked to differences in the molecular readout of chromatin signatures that connect UHRF1 to ubiquitination of histone H3.

  7. These findings indicated that UHRF1 promoted the growth, migration and invasion of MGC803 and SGC7901 cells and inhibited apoptosis via a ROS-associated pathway

  8. The UBL coordinates with other UHRF1 domains that recognize epigenetic marks on DNA and histone H3 to direct ubiquitin to H3. Results show UBLs from other E3s also have a conserved interaction with the E2, Ube2D, highlighting a potential prevalence of interactions between UBLs and E2s.

  9. Findings suggest that UHRF1 is critical for aberrant tumor suppressor genes silencing and sustained growth signaling in hepatoblastoma and that UHRF1 overexpression levels might serve as a prognostic biomarker.

  10. Our novel findings strongly indicate that inactivation of the Notch signaling pathway impedes hepatocellular carcinoma progress via reduction of ICBP90.

  11. Using an integrative approach that combines small angle X-ray scattering, NMR spectroscopy, and molecular dynamics simulations, we characterized the dynamics of the tandem tudor domain-plant homeodomain (TTD-PHD) histone reader module, including its 20-residue interdomain linker.

  12. UHRF1 deficiency leads to the induction of EMT by activating the CXCR4/AKT-JNK/IL-6 signaling pathway, thereby contributing to the expansion of cancer stem-like cells

  13. studies support a noncompetitive model for UHRF1 and DNMT1 chromatin recruitment to replicating chromatin and define a role for hemimethylated linker DNA as a regulator of UHRF1 ubiquitin ligase substrate selectivity.

  14. Lys4 methylation on H3 peptide has an insignificant effect on combinatorial recognition of R2 and K9me2 on H3 by the UHRF1 TTD-PHD. We propose that subtle variations of key residues at the binding pocket determine status specific recognition of histone methyl-lysines by the reader domains.

  15. Study provides evidence that elevated expression of UHRF1 plays an important role in melanoma cell proliferation and progression, and it can be used as a prognostic biomarker for melanoma.

  16. Our data demonstrate for the first time that TIP60 through its MYST domain directly interacts with UHRF1

  17. The emodininduced downregulation of UHRF1 led to an increase in the level of DNA methyltransferase 3A.

  18. Findings confirmed that UHRF1 is a gene driver in medulloblastoma (MB) and, revealed that UHRF1 is in a modulation axis downstream of miR-378. Its promoter region is targeted by miR-378 which negatively regulates its expression in MB cells.

  19. The induced expression of RIP3 by UHRF1 RNAi depends on the presence of Sp1. Remarkably, the ectopic expression of RIP3 in RIP3-null cancer cells results in a decrease in tumor growth in mice. Therefore, our findings offer insights into RIP3 expression control in cancer cells and suggest an inhibitory effect of RIP3 on tumorigenesis.

  20. UHRF1 controls both CDH1 and antisense-directed non coding RNA RCDH1-AS by directly binding this bidirectional promoter region.

Mouse (Murine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. study demonstrates the fundamental role of Uhrf1 in regulating VSMC phenotype by promoting proliferation and dedifferentiation. UHRF1 targeting may hold therapeutic potential in vascular pathologies.

  2. Data indicate the regulatory mechanism of DNA methyltransferase (cytosine-5) 1 (DNMT1) activation by UHRF1 and supports that individual domains of ubiquitin-like-containing PHD and RING finger domains protein 1 (UHRF1) participate and act in concert to maintain DNA methylation patterns.

  3. Findings suggest that Np95 plays an essential role in proliferation and differentiation of aNS/PCs through the regulation of tumor suppressor gene expression in adult neurogenesis.

  4. Uhrf1 regulates germinal center (GC) B cell proliferation and affinity maturation, and its expression in GC B cells is required for virus clearance.

  5. During limb development in mouse embryos, Uhrf1 is expressed in the undifferentiated autopodial mesoderm and in subsequent stages, expression becomes restricted to the interdigital mesoderm. By day 14 post coitum, interdigit regression is almost accomplished and Uhrf gene expression become restricted to zones of the joint formation.

  6. Study report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification.

  7. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 axis has been demonstrated for humans and mice.

  8. These results indicate that Uhrf1 governs cell type-specific transcriptional regulation by controlling the genome-wide DNA methylation status and regulating consequent cell differentiation and skeletal maturation.

  9. UHRF1 ubiquitinates PAF15 at Lys 15 and Lys 24 and promotes its binding to PCNA during late S-phase

  10. Whole genome bisulfite sequencing revealed that blastocysts derived from KO oocytes have a greatly reduced level of CG methylation, suggesting that maternal UHRF1 is essential for maintaining CG methylation, particularly at the imprinting control regions, in preimplantation embryos.

  11. SETDB1 maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 to hemimethylated DNA transiently disrupts SETDB1-dependent H3K9me3 deposition.

  12. deletion of Uhrf1 lead to global DNA hypomethylation with a strong activation of the intracisternal A particle (IAP) family of endogenous retroviral elements, accompanied by an increase in 5-hydroxymethylcytosine

  13. Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation in pluripotent and differentiating cells

  14. results identify UHRF1 as a novel HSP90 client protein and shed light on the regulation of UHRF1 stability and function.

  15. Uhrf1 regulation of the Akt-mTOR signaling pathway is required for invariant natural killer T cell development.

  16. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone recognition.

  17. the histone modification status at the DMRs of imprinted genes may dictate whether DNA methylation could be restored upon UHRF1 re-expression

  18. UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5.

  19. report identifies PARP1 as a novel modulator of two UHRF1-regulated heterochromatin-associated events: the accumulation of H4K20me3 and the clearance of DNMT1

  20. Uhrf1 deficiency resulted in derepression of the gene (Cdkn1a) that encodes the cyclin-dependent kinase inhibitor p21 due to hypomethylation of its promoter region, which resulted in cell-cycle arrest of Treg cells.

Zebrafish Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Dnmt1 stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. DNA hypomethylation is the mechanism underlying the cell cycle block and small liver phenotype caused by uhrf1 depletion.

  3. an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2/cyclin A2 during early vertebrate development

  4. These data provide the first evidence that Uhrf1 and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. uhrf1 is required for physiologic liver growth in both embryos and adults

Pig (Porcine) Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

UHRF1 Antigen Profile

Protein Summary

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with UHRF1

  • ubiquitin like with PHD and ring finger domains 1 (UHRF1) antibody
  • ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1) antibody
  • ubiquitin-like with PHD and ring finger domains 1 (Uhrf1) antibody
  • ubiquitin-like with PHD and ring finger domains 1 (uhrf1) antibody
  • ubiquitin like with PHD and ring finger domains 1 (Uhrf1) antibody
  • AL022808 antibody
  • fb97f09 antibody
  • hNP95 antibody
  • hUHRF1 antibody
  • ICBP90 antibody
  • NP95 antibody
  • RNF106 antibody
  • UHRF1 antibody
  • wu:fb97f09 antibody
  • zgc:63539 antibody

Protein level used designations for UHRF1

E3 ubiquitin-protein ligase UHRF1 , RING finger protein 106 , huNp95 , inverted CCAAT box-binding protein of 90 kDa , nuclear protein 95 , nuclear zinc finger protein Np95 , transcription factor ICBP90 , ubiquitin-like PHD and RING finger domain-containing protein 1 , ubiquitin-like, containing PHD and RING finger domains, 1 , ubiquitin-like-containing PHD and RING finger domains protein 1 , mUhrf1 , liver regeneration-related protein LRRG126 , ubiquitin-like with PHD and ring finger domains 1

29128 Homo sapiens
18140 Mus musculus
316129 Rattus norvegicus
406350 Danio rerio
420154 Gallus gallus
455613 Pan troglodytes
530411 Bos taurus
611463 Canis lupus familiaris
100062347 Equus caballus
100511003 Sus scrofa
100719542 Cavia porcellus
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