anti-phosphodiesterase 6C, CGMP-Specific, Cone, alpha Prime (PDE6C) Antibodies

PDE6C encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDE6C 110855 Q91ZQ1
PDE6C 361752  
PDE6C 5146 P51160
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Top anti-PDE6C Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded brain tissue reacted with PDE6C Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of PDE6C Antibody (Center) in mouse liver tissue lysates (35ug/lane). PDE6C (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p) PDE6C Antibody IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated ELISA, WB PDE6C polyclonal antibody (A01), Lot # 060116JC01 Western Blot analysis of PDE6C expression in HL-60 . Western Blot detection against Immunogen (36.89 KDa) . 50 μL 11 to 12 Days
$305.71
Details
Human Rabbit PE IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

More Antibodies against PDE6C Interaction Partners

Mouse (Murine) phosphodiesterase 6C, CGMP-Specific, Cone, alpha Prime (PDE6C) interaction partners

  1. AIPL1-mediated production of folded PDE6C is markedly elevated in the presence of the inhibitory Pgamma-subunit of PDE6.

  2. A comprehensive in vivo assessment of retinal morphology and function was performed in cpfl1 (cone photoreceptor function loss 1) mice to better define the disease process in this model of cone dystrophies.

  3. the spontaneous mouse mutant cpfl1 that features a lack of cone function and rapid degeneration of the cone photoreceptors represents a homologous mouse model for PDE6C associated achromatopsia.

Human phosphodiesterase 6C, CGMP-Specific, Cone, alpha Prime (PDE6C) interaction partners

  1. Three novel homozygous variants were detected in CNGA3, two novel variants were found in PDE6C. All patients had nonrecordable full-field electroretinography 30-Hz flicker responses, reduced single-flash cone responses but preserved rod responses.

  2. This study reveals two general mechanisms of missense PDE6C mutations underlying retinal diseases: (a) inability of AIPL1 to fold mutant PDE6C proteins leading to complete catalytic inactivity and (b) failure of P gamma regulatory subunit to serve as co-chaperone with AIPL1 in folding of mutant PDE6C.

  3. A novel homozygous PDE6C mutation was identified as the cause of ACHM. In addition, we identified an OPN1SW mutation in the sibling with complete achromatopsia.

  4. Expression of PDE6 in rod photoreceptors show that the cone PDE6 isoform is responsible for the difference in light adaptation between rods and cones.

  5. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).

  6. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6

  7. Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia.

  8. Eleven different PDE6C mutations were found including two nonsense mutations, three mutations affecting transcript splicing as shown by minigene assays, one 1 bp-insertion and five missense mutations

  9. Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders.

  10. analysis of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods

  11. the identification of mutations in the PDE6C gene encoding the catalytic subunit of the cone photoreceptor phosphodiesterase as a cause of autosomal recessive achromatopsia was reported.

PDE6C Antigen Profile

Protein Summary

This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4).

Gene names and symbols associated with PDE6C

  • phosphodiesterase 6C (PDE6C) antibody
  • phosphodiesterase 6C (Pde6c) antibody
  • phosphodiesterase 6C, cGMP specific, cone, alpha prime (Pde6c) antibody
  • ACHM5 antibody
  • COD4 antibody
  • cpfl1 antibody
  • PDE6C antibody
  • PDEA2 antibody

Protein level used designations for PDE6C

phosphodiesterase 6C, cGMP-specific, cone, alpha prime , cone cGMP phosphodiesterase-like , cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'-like , phosphodiesterase 6C, cGMP specific, cone, alpha prime , cyclic nucleotide phosphodiesterase 6c , cGMP phosphodiesterase 6C , cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' , PDE V-C1 , phosphodiesterase, cyclic GMP (cone receptor) , cone cGMP phosphodiesterase a'-subunit

GENE ID SPECIES
486805 Canis lupus familiaris
700261 Macaca mulatta
740456 Pan troglodytes
100343836 Oryctolagus cuniculus
100444869 Pongo abelii
100480480 Ailuropoda melanoleuca
100527954 Cavia porcellus
100597030 Nomascus leucogenys
110855 Mus musculus
361752 Rattus norvegicus
5146 Homo sapiens
281975 Bos taurus
395834 Gallus gallus
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