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Acts as a GTP specific dissociation inhibitor (GDI). Additionally we are shipping phosphodiesterase 6D, CGMP-Specific, Rod, delta Proteins (9) and many more products for this protein.
Showing 10 out of 39 products:
Human Polyclonal PDE6D Primary Antibody for IHC, IHC (p) - ABIN4344439
Thomas, Wright, Le Corre, Micalizzi, Romani, Abhyankar, Saada, Perrault, Amiel, Litzler, Filhol, Elkhartoufi, Kwong, Casanova, Boddaert, Baehr, Lyonnet, Munnich, Burglen, Chassaing, Encha-Ravazi et al.: A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. ... in Human mutation 2014
PDE6delta binds selectively to the C-terminus of RPGR (show RPGR Antibodies) and that this interaction is critical for RPGR's localization to cilia.
Studies indicate that the binding of UNC119 (show UNC119 Antibodies) and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein (show RAC2 Antibodies) Arl3 in a GTP (show AK3 Antibodies)-dependent manner.
Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies.
RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia.
findings indicate that ARL13B (show ARL13B Antibodies), INPP5E, PDE6D, and CEP164 (show CEP164 Antibodies) form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (show MKS1 Antibodies) proteins
Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane.
Results suggest that PrBP/delta exclusively interacts with the soluble fraction of PDE6.
The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS (show ROS1 Antibodies)) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites.
the affinity to PDE6delta and the release by Arl2 (show ARL2 Antibodies)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.
Knockout of Unc119 (show UNC119 Antibodies) partially reversed the transport defect of GRK1 (show GRK1 Antibodies) in cone photoreceptors caused by deletion of Pde6d.
absence of PrBP/delta in retina impairs transport of prenylated proteins, particularly rhodopsin kinase (show GRK1 Antibodies) 1 and cone PDE (show TWIST1 Antibodies), to rod and cone outer segments
Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D, cGMP-specific, rod, delta
, Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D
, GMP-PDE delta
, protein p17
, cGMP-phosphodiesterase delta subunit
, pde6D gene for cGMP-phosphodiesterase delta subunit