Epothilone B
Catalog No. ABIN1027817
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Quick Overview for Epothilone B (ABIN1027817)
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Purpose
- Microtubule stabilizer
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Characteristics
- Microtubule stabilizing agent.
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Purity
- >98 %
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Chemical Name
- (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone
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Formula
- C27H41NO6S
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Solubility
- Soluble to 10 mM in DMSO
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Comment
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Source: Synthetic.
Appearance: White Solid -
Restrictions
- For Research Use only
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Format
- Solid
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Precaution of Use
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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Handling Advice
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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Storage
- -20 °C
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Background
- Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin. Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site. Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis.
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Molecular Weight
- 507.68
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CAS-No
- 152044-54-7
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