Etoposide
Catalog No. ABIN1027829
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Quick Overview for Etoposide (ABIN1027829)
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Purpose
- Topoisomerase II inhibitor
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Characteristics
- Topoisomerase II inhibitor.
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Purity
- >98 %
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Chemical Name
- (5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-β-D-glucopyranoside
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Formula
- C29H32O13
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Solubility
- Soluble to 100 mM in DMSO
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Comment
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Source: Synthetic.
Appearance: White solid -
Restrictions
- For Research Use only
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Format
- Solid
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Precaution of Use
- Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350 Precautionary Phrases: P201-P308 + P313
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Handling Advice
- Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350 Precautionary Phrases: P201-P308 + P313
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Storage
- -20 °C
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Background
- Etoposide inhibits the enzyme topoisomerase II, which unwinds DNA, and be doing so causes the DNA strand to break. Cancer cells are then less likely to be able to repair this damage.
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Molecular Weight
- 588.56
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CAS-No
- 33419-42-0
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