Troglitazone
Catalog No. ABIN1027861
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Quick Overview for Troglitazone (ABIN1027861)
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Purpose
- PPARgamma agonist
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Characteristics
- PPARgamma agonist.
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Purity
- >98 %
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Chemical Name
- 5-{4-[(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin
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Formula
- C24H27NO5S
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Solubility
- Soluble to 100 mM in DMSO and to 10 mM in ethanol
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Comment
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Source: Synthetic.
Appearance: White solid -
Restrictions
- For Research Use only
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Format
- Solid
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Precaution of Use
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R40 - Limited evidence of a carcinogenic effect
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Handling Advice
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R40 - Limited evidence of a carcinogenic effect
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Storage
- -20 °C
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Background
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Troglitazone, a member of the thaizolidinediones, is an anti-diabetic and anti-inflammatory drug. It works by activating peroxisome proliferator-activated receptors (PPARs). It is a ligand to both PPARalpha and gamma. It also contains an alpha-tocopheroyl moiety, potentially giving it vitamin E like activity (which helps in inflammation).
Synonyms: Rezulin -
Molecular Weight
- 441.54
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CAS-No
- 97322-87-7
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