Mouse Complement (Lyophilized) With Diluent

Catalog No. ABIN925150

Supplier Product No.: c201-0005

Product Details

Host: Mouse

Supplier Product No.: c201-0005

Supplier: Rockland

Specificity: The mouse complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 25 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum.

Characteristics: Strain: Mouse - Mixed
Sex: Male

Sterility: Non-sterile

Components: Mouse Complement (Lyophilized) With Diluent

Lysate Type: Normal

Protein Source: Complement

Application Details

Application Notes: pH: normal Immunoelectrophoresis: normal Hemoglobin: normal IgG Concentration: normal Immunoelectrophoresis: normal

Comment:

The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 5.0 mL

Concentration: 82 mg/mL

Handling Advice: Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. COMPLEMENT IS A TEMPERATURE SENSITIVE PRODUCT. IMPROPER STORAGE WILL INACTIVATE COMPLEMENT ACTIVITY.

Storage: 4 °C

Expiry Date: 12 months