The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Manuel Muñoz-Lora, Abdalla, Del Bel Cury, Clemente-Napimoga: "Modulatory effect of botulinum toxin type A on the microglial P2X7/CatS/FKN activated-pathway in antigen-induced arthritis of the temporomandibular joint of rats." in: Toxicon : official journal of the International Society on Toxinology, Vol. 187, pp. 116-121, (2020) (PubMed).
Zhao, Hua, Crowley, Ru, Ni, Shaw, Jiao, Ding, Qu, Hung, Huang, Liu, Ye, Ouyang, Cheng, Liu: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).
McComb, Shutinoski, Thurston, Cessford, Kumar, Sad: "Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 12, pp. 5671-8, (2014) (PubMed).
Xu, Li, Shao, Fan, Ericksen, Liu, Chi, Wang: "Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue virus NS2B-NS3 protease." in: Journal of medicinal chemistry, Vol. 55, Issue 15, pp. 6881-7, (2012) (PubMed).
Aliases for Cathepsin S Proteins
cathepsin S (CTSS) Proteins cathepsin S (Ctss) Proteins cathepsin S L homeolog (ctss.L) Proteins cathepsin S S homeolog (ctss.S) Proteins cathepsin S (ctss) Proteins Cathepsin S (cats) Proteins cats Proteins CTSS Proteins ctss Proteins ctss-a Proteins ctss-b Proteins ctss.1 Proteins MGC69026 Proteins MGC80097 Proteins