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Human MICA Protein expressed in Human Cells - ABIN2005167
Groh, Steinle, Bauer, Spies: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. in Science (New York, N.Y.) 1998
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Study identified the novel role of transcription factors GATA-2 (show GATA2 Proteins) and GATA-3 (show GATA3 Proteins) in suppressing MICA/B expression in HBV-infected human hepatoma cells.
new MICA allelic variant, MICA*007:07, was identified in an individual of Mongol ethnicity in the Inner Mongolia Autonomous Region, northern China
inhibition of BET proteins can enhance the expression of MICA, a ligand of the NKG2D (show KLRK1 Proteins) receptor, in human MM cell lines and primary malignant plasma cells, rendering myeloma cells more efficient to activate NK cell degranulation
results indicate that the polymorphism of rs2256318 in MICA may contribute to the etiology of Preterm birth through interfering with placental development. These findings need to be further validated in larger and multi-ethnic populations.
The results of this study suggested that the MICB (show MICB Proteins)*009N allele might be a risk factor for SLE, whereas the MICB (show MICB Proteins)*014, MICA*010 and MICB (show MICB Proteins)*002 alleles were associated with reduced incidence of SLE in the study population.
New truncated MICA isoforms exhibit a range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherapy
data reveal that MICA and PVR (show PVR Proteins) are directly regulated by human cytomegalovirus immediate early (show JUN Proteins) proteins, and this may be crucial for the onset of an early host antiviral response
This demonstrates for the first time that MICA/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.
selecting a MICA-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA and HLA-B renders identifying a MICA-matched donor readily feasible in clinical practice.
MICA-129 matching is relevant in unrelated hematopoietic stem cell transplantation.
Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants.
HLA class I antigen
, MHC class I chain-related protein A
, stress inducible class I homolog
, inhibitor of carbonic anhydrase
, F10 alpha chain-like
, class I histocompatibility antigen