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MICA Products

(MHC Class I Polypeptide-Related Sequence A (MICA))

Categories

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].

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Featured MICA Categories

MICA Antibodies

High quality antibodies with extensive validation data.

MICA ELISA Kits

Reliable ELISA kits for a wide range of species.

MICA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MICA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS, IF, IHC (p)
Validations
  • (2)
  • (7)
Cat. No. ABIN652566
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IP
Validations
  • (3)
  • (3)
Cat. No. ABIN94329
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), IF (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN728788
Quantity 100 μL
Datasheet Datasheet

Recommended MICA ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968602
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN411398
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6719703
Quantity 1 kit
Datasheet Datasheet

Recommended MICA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275256
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275255
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275254
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MICA products

Srpan, Ambrose, Karampatzakis, Saeed, Cartwright, Guldevall, De Matos, Önfelt, Davis: "Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells." in: The Journal of cell biology, Vol. 217, Issue 9, pp. 3267-3283, (2018) (PubMed).

Chen, Zhidan, Xia, Zhaoxia, Qing, Qiang, Haipeng, Hengxiao: "Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway." in: International immunopharmacology, Vol. 35, pp. 307-14, (2016) (PubMed).

Zanetti, Ziblat, Torres, Zwirner, Bouzat: "Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells." in: The Journal of biological chemistry, Vol. 291, Issue 32, pp. 16541-52, (2016) (PubMed).

Tyciakova, Matuskova, Bohovic, Polakova, Toro, Skolekova, Kucerova: "Genetically engineered mesenchymal stromal cells producing TNF? have tumour suppressing effect on human melanoma xenograft." in: The journal of gene medicine, (2015) (PubMed).

Shi, Li, Couturier, Yang, Guo, He, Lewis, Zhou: "Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism." in: The open rheumatology journal, Vol. 9, pp. 60-4, (2015) (PubMed).

Taniguchi, Koyano, Suzutani, Goishi, Ito, Morioka, Nakamura, Yamada, Oka, Inoue: "A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease." in: Infection, Vol. 43, Issue 3, pp. 353-9, (2015) (PubMed).

Xiang, Liu, Zheng, Liu, Lv, Gao, Hu, Lam, Chan, Yang, Chen, Tsao, Bonneville, Lau, Tu: "Targeted activation of human V?9V?2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease." in: Cancer cell, Vol. 26, Issue 4, pp. 565-76, (2014) (PubMed).

Umebayashi, Kiyota, Koya, Tanaka, Onishi, Katano, Morisaki: "An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro." in: Anticancer research, Vol. 34, Issue 8, pp. 4509-19, (2014) (PubMed).

Morisaki, Hirano, Koya, Kiyota, Tanaka, Umebayashi, Onishi, Katano: "NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors." in: Anticancer research, Vol. 34, Issue 8, pp. 4529-38, (2014) (PubMed).

Gómez-Lomelí, Bravo-Cuellar, Hernández-Flores, Jave-Suárez, Aguilar-Lemarroy, Lerma-Díaz, Domínguez-Rodríguez, Sánchez-Reyes, Ortiz-Lazareno: "Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor." in: Cancer cell international, Vol. 14, Issue 1, pp. 100, (2014) (PubMed).

Synonyms and alternative names related to MICA

MHC class I polypeptide-related sequence A (MICA), MIC-A, PERB11.1

Protein level used designations for MICA

  • HLA class I antigen
  • MHC class I chain-related protein A
  • stress inducible class I homolog
  • F10 alpha chain-like
  • class I histocompatibility antigen
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