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MICA Protein (AA 23-308) (Fc Tag)

MICA Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1692277
  • Target See all MICA Proteins
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 23-308
    Origin
    • 22
    • 1
    Human
    Source
    • 12
    • 5
    • 3
    • 2
    • 1
    Human Cells
    Purification tag / Conjugate
    This MICA protein is labelled with Fc Tag.
    Purpose
    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-Fc)
    Sequence
    AEPHSLRYNL TVLSWDGSVQ SGFLTEVHLD GQPFLRCDRQ KCRAKPQGQW AEDVLGNKTW DRETRDLTGN GKDLRMTLAH IKDQKEGLHS LQEIRVCEIH EDNSTRSSQH FYYDGELFLS QNLETEEWTM PQSSRAQTLA MNVRNFLKED AMKTKTHYHA MHADCLQELR RYLKSGVVLR RTVPPMVNVT RSEASEGNIT VTCRASGFYP WNITLSWRQD GVSLSHDTQQ WGDVLPDGNG TYQTWVATRI CQGEEQRFTC YMEHSGNHST HPVPSGKVLV LQSHWQVDDI EGRMDEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
    Characteristics

    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-Fc)

    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product MICA Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Alternative Name
    MHC Class I Polypeptide-Related Sequence A/MICA (MICA Products)
    Synonyms
    MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
    Background
    Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA is produced with our HEK293 expression system. The target protein is expressed with sequence (Ala23-Glu308) of Human MICA fused with a FC tag at the C-terminus.
    MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with β-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
    Molecular Weight
    59.9 kDa
    UniProt
    Q29983
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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