AIF Products
(Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
Categories
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010].
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Featured AIF Categories
AIF Antibodies
High quality antibodies with extensive validation data.
AIF ELISA Kits
Reliable ELISA kits for a wide range of species.
AIF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended AIF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Pig, Rat
Application
WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro)
Validations
- (2)
- (10)
Cat. No.
ABIN724010
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (1)
- (9)
Cat. No.
ABIN968950
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Pig, Rat
Application
WB, ELISA, IHC, IF
Validations
- (6)
Cat. No.
ABIN2630015
Quantity
100 μg
Datasheet
Datasheet
Recommended AIF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974975
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964969
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953879
Quantity
96 tests
Datasheet
Datasheet
Recommended AIF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344663
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121875
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344662
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our AIF products
: "RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants." in: Frontiers in genetics, Vol. 12, pp. 728791, (2021) (PubMed).: "Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication." in: Neurochemistry international, Vol. 139, pp. 104791, (2020) (PubMed).
: "Salivary proteome patterns of individuals exposed to High Altitude." in: Archives of oral biology, Vol. 96, pp. 104-112, (2019) (PubMed).
: "Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment." in: Neuron, Vol. 102, Issue 6, pp. 1127-1142.e3, (2019) (PubMed).
: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).
: "Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer's Disease Mouse Model." in: International journal of molecular sciences, Vol. 18, Issue 8, (2017) (PubMed).
: "Mechanism of apoptosis induction in human hepatocellular carcinoma cells following treatment with a gecko peptides mixture." in: Biomedical reports, Vol. 5, Issue 1, pp. 73-78, (2016) (PubMed).
: "Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway." in: Stem cells international, Vol. 2016, pp. 1690896, (2016) (PubMed).
: "Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel." in: Oncology reports, Vol. 34, Issue 3, pp. 1589-98, (2016) (PubMed).
: "Zinc protects human kidney cells from depleted uranium-induced apoptosis." in: Basic & clinical pharmacology & toxicology, Vol. 114, Issue 3, pp. 271-80, (2015) (PubMed).
Synonyms and alternative names related to AIF
apoptosis inducing factor mitochondria associated 1 (AIFM1), allograft inflammatory factor 1 (AIF1), Apoptosis inducing factor (AIF), apoptosis-inducing factor 1, mitochondrial (LOC412212), apoptosis inducing factor (aif), apoptosis inducing factor, mitochondria associated 1 (AIFM1), apoptosis inducing factor, mitochondria associated 1 (aifm1), apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), apoptosis inducing factor mitochondria associated 1 (aifm1), apoptosis-inducing factor, mitochondrion-associated 1 (Aifm1), apoptosis inducing factor, mitochondria associated 1 (Aifm1), apoptosis-inducing factor, mitochondrion-associated 1 (aifm1), AIF, aif, Aif, AIFM1, AIFsh2, CG7263, CMTX4, COWCK, COXPD6, DDBDRAFT_0187853, DDBDRAFT_0191137, DDB_0187853, DDB_0191137, DmAIF, Dmel\\CG7263, GB16024, Hq, mAIF, PCD8, PDCD8, pdcd8, Pdcd8, zgc:91994Protein level used designations for AIF
- apoptosis-inducing factor 1, mitochondrial
- programmed cell death 8 (apoptosis-inducing factor)
- striatal apoptosis-inducing factor
- daintain
- AIF-PA
- AIF-PB
- AIF-PC
- CG7263-PA
- CG7263-PB
- CG7263-PC
- apoptosis inducing factor
- programmed cell death 8
- apoptosis-inducing factor, mitochondrion-associated, 1
- mammary apoptosis inducing factor
- flavoprotein and apoptosis inductor
- apoptosis-inducing factor 1, mitochondrial-like
- harlequin
- programmed cell death protein 8
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