Aneurysm, Intracranial Berry 3 antibody (AA 22-146)
Cited in 1 publication.
The Rabbit Polyclonal anti-Aneurysm, Intracranial Berry 3 antibody (ABIN2668550) specifically detects Aneurysm, Intracranial Berry 3 in IHC and WB.
The antibody is reactive with Human and Mouse samples.
(1 reference)
Catalog No. ABIN2668550
$444.62
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Quick Overview for Aneurysm, Intracranial Berry 3 antibody (AA 22-146) (ABIN2668550)
Target
Aneurysm, Intracranial Berry 3 (ANIB3)
Reactivity
Human, Mouse
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
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Binding Specificity
- AA 22-146
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Purpose
- AIB3 antibody (pAb)
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Purification
- Affinity Purified
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Immunogen
- This AIB3 antibody was raised against a recombinant protein corresponding to amino acids 22-146 of mouse AIB3.
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Purified IgG in 70 mM Tris-HCl ( pH 8), 105 mM NaCl, 70 mM glycine, 30 % glycerol, 0.035 % sodium azide and 0.05 % BSA.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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Storage
- -20 °C
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Storage Comment
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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Expiry Date
- 24 months
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: "Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation ..." in: Cancer research, Vol. 64, Issue 19, pp. 7169-77, (2004) (PubMed).
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- Aneurysm, Intracranial Berry 3 (ANIB3)
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Alternative Name
- AIB3
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Target Type
- Chemical
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Background
- AIB3 (Amplified in Breast Cancer 3, Nuclear Receptor Coactivator 6, NCoA6) is a chromatin-associated protein that interacts with nuclear hormone receptors (antibodies, kits and proteins) to modify their activity as transcriptional activators. AIB3 / NCoA6 was originally isolated as a ligand-dependent nuclear receptor interacting protein. It is a co-activator that directly binds nuclear receptors and stimulates their transcriptional activity in a hormone-dependent fashion. AIB3 is a multifunctional co-activator necessary for transcriptional activation of a wide spectrum of target genes. AIB3 is involved in growth, development, wound healing and maintenance of energy homeostasis. It can enhance the transcriptional activation of a variety of transcription factors and also associates with a number of important regulators of transcription including CBP and p300. AIB3 / NCoA6 is a component of at least three distinct MLL complexes, suggesting that AIB3 plays a fundamental role in transcriptional activation by modulating chromatin structure through histone methylation. AIB3 may also be involved in the co-activation of the NF-kappa-B pathway. It is amplified and overexpressed in breast, colon and lung cancers. AIB3 function is essential in mammalian development as AIB3 null embryos do not survive. Additionally, AIB null spontaneously undergo apoptosis, indicating that AIB3 has anti-apoptotic and pro-survival functions.
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Molecular Weight
- 250 kDa
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Gene ID
- 23054
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NCBI Accession
- NP_062799
Target
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