The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008].
Zhang, Rosenberg: "Diversifying selection of the tumor-growth promoter angiogenin in primate evolution." in: Molecular biology and evolution, Vol. 19, Issue 4, pp. 438-45, (2002) (PubMed).
Kurachi, Davie, Strydom, Riordan, Vallee: "Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor." in: Biochemistry, Vol. 24, Issue 20, pp. 5494-9, (1986) (PubMed).
Aliases for Angiogenin Proteins
angiogenin (ANG) Proteins angiogenin, ribonuclease, RNase A family, 5 (Ang) Proteins angiogenin, ribonuclease, RNase A family, 5 (ANG) Proteins angiogenin (Ang) Proteins ribonuclease A family member k6 (RNASE6) Proteins AI385586 Proteins ALS9 Proteins ANG Proteins Ang1 Proteins ANG1 Proteins HEL168 Proteins RNASE4 Proteins RNASE5 Proteins Rnase5 Proteins Rnase5a Proteins