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ANTXR1 Products

(anthrax Toxin Receptor 1 (ANTXR1))
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008].

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Featured ANTXR1 Categories

ANTXR1 Antibodies

High quality antibodies with extensive validation data.

ANTXR1 ELISA Kits

Reliable ELISA kits for a wide range of species.

ANTXR1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ANTXR1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN185280
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB
Validations
  • (2)
Cat. No. ABIN205769
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN499363
Quantity 0.1 mg
Datasheet Datasheet

Recommended ANTXR1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964899
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1122056
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1122057
Quantity 96 tests
Datasheet Datasheet

Recommended ANTXR1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088755
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088756
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3128695
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ANTXR1 products

Jayawardena, Burga, Easingwood, Takizawa, Wolf, Bostina: "Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 46, pp. E10934-E10940, (2019) (PubMed).

Matsuda, Ohga, Hida, Muraki, Tsuchiya, Kurosu, Akino, Shih, Totsuka, Klagsbrun, Shindoh, Hida: "Isolated tumor endothelial cells maintain specific character during long-term culture." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 947-54, (2010) (PubMed).

Wei, Lu, Chaudry, Leppla, Cohen: "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin." in: Cell, Vol. 124, Issue 6, pp. 1141-54, (2006) (PubMed).

Werner, Kowalczyk, Faundez: "Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23227-36, (2006) (PubMed).

Rainey, Wigelsworth, Ryan, Scobie, Collier, Young: "Receptor-specific requirements for anthrax toxin delivery into cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13278-83, (2005) (PubMed).

Hotchkiss, Basile, Spring, Bonuccelli, Lisanti, Terman: "TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen." in: Experimental cell research, Vol. 305, Issue 1, pp. 133-44, (2005) (PubMed).

Sanz, Calasanz, Andreu, Richard, Prosper, Fernandez-Luna: "NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells." in: The Biochemical journal, Vol. 384, Issue Pt 2, pp. 281-6, (2004) (PubMed).

Nanda, Carson-Walter, Seaman, Barber, Stampfl, Singh, Vogelstein, Kinzler, St Croix: "TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)." in: Cancer research, Vol. 64, Issue 3, pp. 817-20, (2004) (PubMed).

Widlak, Li, Wang, Garrard: "Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48404-9, (2001) (PubMed).

Parrish, Li, Klotz, Ledwich, Wang, Xue: "Mitochondrial endonuclease G is important for apoptosis in C. elegans." in: Nature, Vol. 412, Issue 6842, pp. 90-4, (2001) (PubMed).

Synonyms and alternative names related to ANTXR1

anthrax toxin receptor 1 (ANTXR1), anthrax toxin receptor 1 (Antxr1), 2310008J16Rik, 2810405N18Rik, Antrx1, ANTXR1, ATR, TEM8, Tem8

Protein level used designations for ANTXR1

  • anthrax toxin receptor 1
  • tumor endothelial marker 8
  • anthrax toxin receptor 1-like
  • 2310008J16Rik
  • 2810405N18Rik
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