ANTXR1 Products
(anthrax Toxin Receptor 1 (ANTXR1))
Categories
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008].
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Featured ANTXR1 Categories
ANTXR1 Antibodies
High quality antibodies with extensive validation data.
ANTXR1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ANTXR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ANTXR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (2)
Cat. No.
ABIN544900
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ICC
Validations
- (2)
- (2)
Cat. No.
ABIN541433
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN392154
Quantity
400 μL
Datasheet
Datasheet
Recommended ANTXR1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964899
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1122056
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1122057
Quantity
96 tests
Datasheet
Datasheet
Recommended ANTXR1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121857
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345159
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345161
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ANTXR1 products
: "Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 46, pp. E10934-E10940, (2019) (PubMed).: "Isolated tumor endothelial cells maintain specific character during long-term culture." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 947-54, (2010) (PubMed).
: "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin." in: Cell, Vol. 124, Issue 6, pp. 1141-54, (2006) (PubMed).
: "Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23227-36, (2006) (PubMed).
: "Receptor-specific requirements for anthrax toxin delivery into cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13278-83, (2005) (PubMed).
: "TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen." in: Experimental cell research, Vol. 305, Issue 1, pp. 133-44, (2005) (PubMed).
: "NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells." in: The Biochemical journal, Vol. 384, Issue Pt 2, pp. 281-6, (2004) (PubMed).
: "TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)." in: Cancer research, Vol. 64, Issue 3, pp. 817-20, (2004) (PubMed).
: "Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48404-9, (2001) (PubMed).
: "Mitochondrial endonuclease G is important for apoptosis in C. elegans." in: Nature, Vol. 412, Issue 6842, pp. 90-4, (2001) (PubMed).
Synonyms and alternative names related to ANTXR1
anthrax toxin receptor 1 (ANTXR1), anthrax toxin receptor 1 (Antxr1), 2310008J16Rik, 2810405N18Rik, Antrx1, ANTXR1, ATR, TEM8, Tem8Protein level used designations for ANTXR1
- anthrax toxin receptor 1
- tumor endothelial marker 8
- anthrax toxin receptor 1-like
- 2310008J16Rik
- 2810405N18Rik
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