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CD79b antibody

CD79B Reactivity: Human FACS, WB, IP, IHC Host: Mouse Monoclonal CB3-1 unconjugated
Catalog No. ABIN1027694
  • Target See all CD79b (CD79B) Antibodies
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Reactivity
    • 115
    • 47
    • 18
    • 6
    • 6
    Human
    Host
    • 63
    • 48
    • 13
    • 9
    • 4
    • 2
    Mouse
    Clonality
    • 75
    • 58
    • 1
    Monoclonal
    Conjugate
    • 69
    • 17
    • 14
    • 11
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD79b antibody is un-conjugated
    Application
    • 73
    • 71
    • 40
    • 36
    • 32
    • 14
    • 13
    • 11
    • 11
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
    Specificity
    The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Fraction of Ig-associated molecules isolated from Ramos B cells
    Clone
    CB3-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD79B Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Zheng, Fuji, Elkins, Yu, Fuh, Chuh, Tan, Hongo, Raab, Kozak, Williams, McDorman, Eaton, Ebens, Polson: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." in: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).

    Dornan, Bennett, Chen, Dennis, Eaton, Elkins, French, Go, Jack, Junutula, Koeppen, Lau, McBride, Rawstron, Shi, Yu, Yu, Yue, Zheng, Ebens, Polson: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).

    Matutes: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." in: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).

    DArena, Cascavilla, Musto, Colella Bisogno, Pistolese, Carotenuto: "CD79b expression in B-cell chronic lymphocytic leukemia." in: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).

    Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

    Nakamura, Kubagawa, Cooper: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).

  • Target
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Alternative Name
    CD79b (CD79B Products)
    Synonyms
    B29 antibody, Ig-beta antibody, Igb antibody, Igbeta antibody, AGM6 antibody, IGB antibody, CD79B antigen antibody, CD79b molecule antibody, Cd79b antibody, CD79B antibody
    Background
    CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB
    Gene ID
    974
    UniProt
    P40259
    Pathways
    BCR Signaling
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