HLA-DR antibody
(4 references)-
- Target See all HLA-DR products
- HLA-DR
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Reactivity
- Human, Dog, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HLA-DR antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Specificity
- The mouse monoclonal antibody L243 recognizes specifically an extracellular epitope on HLA-DR molecules, both peptide-loaded and empty.
- Cross-Reactivity (Details)
- Human, Non-Human Primates, Canine (Dog)
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Human B lymphocytes
- Clone
- L243
- Isotype
- IgG2a kappa
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anti-HLA-DR (HLA-DR) antibody (FITC)
HLA-DR Reactivity: Human FACS Host: Mouse Monoclonal MEM-12 FITC
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reactivity: Human FACS, WB, IHC, ISt, StM Host: Mouse Monoclonal TAL 1B5 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reactivity: Human FACS, WB, IP Host: Mouse Monoclonal MEM-12 unconjugated
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR Reactivity: Human, Dog, Non-Human Primate FACS Host: Mouse Monoclonal L243 PE
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reactivity: Human FACS, WB, IHC, IF, ISt, StM Host: Mouse Monoclonal SPM289 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reactivity: Human FACS, IP Host: Mouse Monoclonal HL-39 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reactivity: Human, Dog, Non-Human Primate FACS, WB, IP, IHC (fro), IHC (p), ICC, Func Host: Mouse Monoclonal L243 unconjugated
anti-HLA-DR (HLA-DR) antibody (PerCP)HLA-DR Reactivity: Human FACS Host: Mouse Monoclonal MEM-12 PerCP
anti-HLA-DR (HLA-DR) antibody (APC)HLA-DR Reactivity: Human FACS Host: Mouse Monoclonal MEM-12 APC
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR Reactivity: Human FACS Host: Mouse Monoclonal MEM-12 PE
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- Application Notes
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).
: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).
: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, (2003) (PubMed).
: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, (2002) (PubMed).
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: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).
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- Target
- HLA-DR
- Alternative Name
- HLA-DR (HLA-DR Products)
- Background
- HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.
- Pathways
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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