CCL20 antibody (Chemokine (C-C Motif) Ligand 20) (Biotin)

Details for Product anti-CCL20 Antibody No. ABIN1043839, Supplier: Log in to see
Antigen
  • MIP-3ALPHA
  • CCL20
  • si:dkey-150o13.1
  • CKb4
  • LARC
  • MIP-3-alpha
  • MIP-3a
  • MIP3A
  • SCYA20
  • ST38
  • MIP-3A
  • MIP-3[a]
  • Scya20
  • exodus-1
  • C-C motif chemokine ligand 20
  • chemokine (C-C motif) ligand 20b
  • chemokine (C-C motif) ligand 20
  • CCL20
  • ccl20b
  • Ccl20
Reactivity
Mouse (Murine)
179
67
30
5
4
2
2
1
1
Host
Rat
78
71
64
20
Clonality (Clone)
Monoclonal ()
Conjugate
This CCL20 antibody is conjugated to Biotin
24
14
12
8
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6
4
4
4
4
4
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
163
85
30
29
26
14
13
7
7
6
6
4
4
3
3
2
2
2
2
1
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Options
Supplier
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Supplier Product No.
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Immunogen Anti-MIP-3alpha (RAT) Monoclonal Antibody was produced in rat by repeated immunizations with mature full length recombinant mouse MIP-3alpha produced in E.coli followed by hybridoma development.
Immunogen Type: Recombinant Protein
Clone 4N5F7
Isotype IgG
Specificity This product was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for mouse MIP-3alpha protein. A BLAST analysis was used to suggest cross-reactivity with MIP-3alpha from mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with MIP-3alpha from other sources has not been determined.
Characteristics MIP-3alpha (also known as C-C motif chemokine 20, small-inducible cytokine A20, macrophage inflammatory protein 3 alpha, MIP-3-alpha, liver and activation-regulated chemokine, CC chemokine LARC and beta chemokine exodus-1) is a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. MIP-3alpha inhibits proliferation of myeloid progenitors in colony formation assays and may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. MIP-3alpha also possesses antibacterial activity against E.coli and S.aureus. MIP-3alpha is a secreted protein that is expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of expression are also seen in thymus, prostate, testis, small intestine and colon. C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Purification purified
Alternative Name MIP-3alpha (CCL20 Antibody Abstract)
Background MIP-3α (also known as C-C motif chemokine 20, small-inducible cytokine A20, macrophage inflammatory protein 3 alpha, MIP-3-alpha, liver and activation-regulated chemokine, CC chemokine LARC and beta chemokine exodus-1) is a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. MIP-3α inhibits proliferation of myeloid progenitors in colony formation assays and may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. MIP-3α also possesses antibacterial activity against E.coli and S.aureus. MIP-3α is a secreted protein that is expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of expression are also seen in thymus, prostate, testis, small intestine and colon. C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Synonyms: MIP-3α , CCL20, C-C motif chemokine 20, small-inducible cytokine A20, macrophage inflammatory protein 3 alpha, MIP-3-alpha, liver and activation-regulated chemokine, CC chemokine LARC and beta chemokine exodus-1
Gene ID 20297
NCBI Accession NP_001153210
UniProt O89093
Application Notes Specific conditions for reactivity should be optimized by the end user.
Comment

Gene Name: CCL20

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Chemokine (C-C Motif) Ligand 20 (CCL20) antibody (Biotin) (ABIN1043839) Western Blot of Mouse MIP 3α (RAT) antibody Lane 1: mouse recombinant MIP-3a Lane 2: ...
Product cited in: Lisignoli, Manferdini, Codeluppi, Piacentini, Grassi, Cattini, Filardo, Facchini: "CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups." in: Journal of cellular physiology, Vol. 221, Issue 1, pp. 154-60, 2009 (PubMed).

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