TPT1 antibody

Catalog No. ABIN1077430

This Rabbit Monoclonal antibody specifically detects TPT1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TPT1 antibody (ABIN1077430)

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TPT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TPT1 Antibody

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal TPT1 antibody was raised against a 19 amino acid peptide near the center of human TPT1.

Isotype: IgG

Application Details

Application Notes: TPT1 antibody can be used for detection of TPT1 by Western blot at 0.5 - 1 μg/mL.

Comment:

(IN) Translationally-controlled tumor protein 1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: TPT1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for TPT1

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Alternative Name: TPT1

Background: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
Synonyms: Tumor protein translationally-controlled 1, translationally-controlled tumor protein, TCTP, fortilin, histamine-releasing factor, HRF, p23

Molecular Weight: 19 kDa (calculated)

Gene ID: 7178

NCBI Accession: NP_003286

Pathways: Response to Water Deprivation, Regulation of Cell Size, Negative Regulation of intrinsic apoptotic Signaling