LMAN1 antibody (C-Term)

Catalog No. ABIN1077459

This anti-LMAN1 antibody is a Rabbit Monoclonal antibody detecting LMAN1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for LMAN1 antibody (C-Term) (ABIN1077459)

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LMAN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1H6D8G7

Product Details anti-LMAN1 Antibody

Binding Specificity: C-Term

Specificity: At least two isoforms of ERGIC53 are known to exist.

Purification: Affinity chromatography purified via peptide column

Immunogen: Mouse monoclonal ERGIC53 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERGIC53.

Isotype: IgG1

Application Details

Application Notes: ERGIC53 antibody can be used for detection of ERGIC53 by Western blot at 1 - 2 μg/mL.

Comment:

(CT) Endoplasmic reticulum-golgi intermediate compartment protein 53

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: ERGIC53 Monoclonal antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for LMAN1

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Alternative Name: LMAN1

Background: ERGIC53, also known as lectin mannose-binding 1 (LMAN1) protein is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
Synonyms: Lectin mannose-binding 1, LMAN1, endoplasmic reticulum-golgi intermediate compartment protein 53, ERGIC-53, F5F8D, FMFD1, MCFD1, MR60, gp58

Molecular Weight: 56 kDa (calculated)

Gene ID: 3998

NCBI Accession: NP_005561