SMN1 antibody

Catalog No. ABIN108566

The Mouse Monoclonal anti-SMN1 antibody has been validated for WB, ELISA, IF, IP, ICC, IHC (p) and FACS. It is suitable to detect SMN1 in samples from Human, Mouse and Xenopus laevis. There are 2+ publications available.

Quick Overview for SMN1 antibody (ABIN108566)

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Reactivity: Human, Mouse, Xenopus laevis

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 2B1

Product Details anti-SMN1 Antibody

Purification: Protein A

Immunogen: Purified recombinant His 6 tagged-SMN protein (human)

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try at IHC-P: Use a concentration of 5 μg/mL. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocolWB: Use at an assay dependent dilution. Detects a band of approximately 42 kDa (predicted molecular weight: 35 kDa)Flow Cyt: Use 1 μg for 106 cells.

Comment:

Myeloma, fusion partners: A/J Sp2/0 cell line,

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS 0.1 % sodium azide,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-SMN1 antibody (ABIN108566)

Grondard, Biondi, Armand, Lécolle, Della Gaspera, Pariset, Li, Gallien, Vidal, Chanoine, Charbonnier: "Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 33, pp. 7615-22, (2005) (PubMed).

Liu, Dreyfuss: "A novel nuclear structure containing the survival of motor neurons protein." in: The EMBO journal, Vol. 15, Issue 14, pp. 3555-65, (1996) (PubMed).

Target Details for SMN1

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Alternative Name: Gemin 1

Background: Synonyms:
BCD541 antibody,Gemin 1 antibody,Gemin-1 antibody,Gemin1 antibody,OTTHUMP00000125198antibody,OTTHUMP00000223567 antibody,OTTHUMP00000223568 antibody,OTTHUMP00000224066antibody,OTTHUMP00000226924 antibody,SMA 1 antibody,SMA 2 antibody,SMA 3 antibody,SMA 4 antibody,SMAantibody,SMA@ antibody,SMA1 antibody,SMA2 antibody,SMA3 antibody,SMA4 antibody,SMN 1 antibody,SMNantibody,SMN-1 antibody,SMN1 antibody,SMNT antibody,Survival motor neuron protein antibody,Survival ofmotor neuron 1 (telomeric) antibody,survival of motor neuron 1 antibody,Survival of motor neuron 1, telomericantibody,T-BCD541 antibody

Gene ID: 6606, 6607, 20595

OMIM: 600354

UniProt: Q16637, P97801

Pathways: Ribonucleoprotein Complex Subunit Organization