FMR1 antibody (C-Term)

Catalog No. ABIN108598

This Mouse Monoclonal antibody specifically detects FMR1 in WB, ELISA, IF, IP and ICC. It exhibits reactivity toward Drosophila melanogaster and has been mentioned in 7+ publications.

Quick Overview for FMR1 antibody (C-Term) (ABIN108598)

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reactivity: Drosophila melanogaster

Host: Mouse

Clonality: Monoclonal

Conjugate: This FMR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 6A15

Product Details anti-FMR1 Antibody

Binding Specificity: C-Term

No Cross-Reactivity: Human

Cross-Reactivity (Details): Fruit fly (Drosophila melanogaster) Does not react with Human

Purification: Protein A

Immunogen: His-dFMR1 fusion protein (Drosophilia melanogaster) (C-terminal 580aa).

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try at IP: Use at 25 μg/mg of lysate WB: Use at an assay dependent dilution. Detects a band of approximately 85 kDa (predicted molecular weight: 82 kDa)

Comment:

Myeloma, fusion partners: SP2/0

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS 0.1 % sodium azide,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-FMR1 antibody (ABIN108598)

Callan, Clements, Ahrendt, Zarnescu: "Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain." in: Brain research, Vol. 1462, pp. 151-61, (2012) (PubMed).

Lim, Lee, Choi, Kilman, Kim, Park, Jang, Allada, Choe: "The novel gene twenty-four defines a critical translational step in the Drosophila clock." in: Nature, Vol. 470, Issue 7334, pp. 399-403, (2011) (PubMed).

Monzo, Dowd, Minden, Sisson: "Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila." in: Developmental biology, Vol. 340, Issue 2, pp. 408-18, (2010) (PubMed).

Callan, Cabernard, Heck, Luois, Doe, Zarnescu: "Fragile X protein controls neural stem cell proliferation in the Drosophila brain." in: Human molecular genetics, Vol. 19, Issue 15, pp. 3068-79, (2010) (PubMed).

Kwak, Drier, Barbee, Ramaswami, Yin, Wickens: "GLD2 poly(A) polymerase is required for long-term memory." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 38, pp. 14644-9, (2008) (PubMed).

Monzo, Papoulas, Cantin, Wang, Yates, Sisson: "Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 48, pp. 18160-5, (2006) (PubMed).

Wan, Dockendorff, Jongens, Dreyfuss: "Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein." in: Molecular and cellular biology, Vol. 20, Issue 22, pp. 8536-47, (2000) (PubMed).

Target Details for FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Alternative Name: Drosophila FMR1

Background: Synonyms:
Drosophila FMR1 antibody,dFMR antibody,dFMR1 antibody,dFXR antibody,Drosophila fragile X mentalretardation protein antibody,FMRP antibody,Fragile X mental retardation 1 antibody,Fragile X mental retardation1 protein antibody,fragile X mental retardation protein antibody,FRAXA antibody,Protein FMR1antibody

Gene ID: 37528, 23879

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development