FASL antibody (Fas Ligand (TNF Superfamily, Member 6)) (Extracellular Domain)

Details for Product anti-FASL Antibody No. ABIN108724, Supplier: Log in to see
Antigen
  • ALPS1B
  • APT1LG1
  • APTL
  • CD178
  • CD95-L
  • CD95L
  • FASL
  • TNFSF6
  • fasl
  • Fas-L
  • Faslg
  • Tnfsf6
  • gld
  • Apt1Lg1
  • Fasl
  • FASLG
  • zgc:162027
  • Fas ligand
  • Fas ligand L homeolog
  • Fas ligand (TNF superfamily, member 6)
  • FASLG
  • faslg.L
  • Fasl
  • Faslg
  • faslg
Alternatives
anti-Human FASL antibody for Flow Cytometry
Epitope
Extracellular Domain
21
21
16
16
13
12
7
6
6
5
5
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
374
141
83
20
6
4
3
3
2
1
Host
Mouse
199
176
48
29
9
6
1
Clonality (Clone)
Monoclonal ()
Conjugate
This FASL antibody is un-conjugated
39
28
28
8
7
7
6
5
5
4
4
4
4
4
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
Application
Cell-ELISA (cELISA), Flow Cytometry (FACS)
241
215
122
89
76
69
26
26
25
24
17
13
12
10
6
5
3
2
2
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen genetic immunisation with cDNA encoding human FasL (extracellular domain)
Clone GM-5F4
Isotype IgG1
Specificity GM5F4 recognises FASL transiently expressed on the cell surface of transfected BOSC cells.
Purification Protein G
Plasmids, Primers & others Plasmids, Primers & others FASL products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name FASL (FASL Antibody Abstract)
Background The FAS ligand (FASL, CD95), a member of the tumor necrosis factor family, induces apoptosis in FAS-bearing cells. GM5F4 against this transmembrane receptor was generated by genetic immunisation.
UniProt P48023
Pathways Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Application Notes Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CD95, Fas ligand

Restrictions For Research Use only
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
 image for anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (Extracellular Domain) antibody (ABIN108724) Specificity testing of GM5F4. BOSC cells were transiently transfected with an express...
Background publications Suda, Hashimoto, Tanaka, Ochi, Nagata: "Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing." in: The Journal of experimental medicine, Vol. 186, Issue 12, pp. 2045-50, 1998 (PubMed).

Nagata: "Apoptosis mediated by the Fas system." in: Progress in molecular and subcellular biology, Vol. 16, pp. 87-103, 1997 (PubMed).

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