MMP2 antibody (AA 242-396)

Catalog No. ABIN1098146

Product Details anti-MMP2 Antibody

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Binding Specificity: AA 242-396

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: MMP2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. Coli.

Clone: 4D1E2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MMP2 antibody (ABIN1098146)

Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: "MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients." in: British journal of cancer, Vol. 106, Issue 9, pp. 1495-8, (2012) (PubMed).

Hajighasemi: "Profiles of MMP-2 expression in Jurkat, Molt-4 and U937 cells." in: Iranian journal of immunology : IJI, Vol. 8, Issue 2, pp. 120-6, (2011) (PubMed).

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2 (MMP2 Products)

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 73.8 kDa

Gene ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response