ADAMTSL1 antibody (N-Term)

Catalog No. ABIN1105253

The Mouse Monoclonal anti-ADAMTSL1 antibody is suitable to detect ADAMTSL1 in samples from Human. It has been validated for WB and EIA.

Quick Overview for ADAMTSL1 antibody (N-Term) (ABIN1105253)

Target: ADAMTSL1 (ADAMTS-Like 1 (ADAMTSL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADAMTSL1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: IBL-5-25

Product Details anti-ADAMTSL1 Antibody

Binding Specificity: N-Term

Specificity: Monoclonal antibody 1B2-8-2 reacts with Punctin-1 (ADAMTSL-1). It recognizes the first thrombospondin repeat near the N-terminal and reacts with molecular species of 55 kDa or a doublet of 55 k Da and 60 kDa (glycosylated form). Note that proteolysis of Punctin-1 has been described and additional smaller bands may also be obtained.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Protein G, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for ADAMTSL1

Target: ADAMTSL1 (ADAMTS-Like 1 (ADAMTSL1))

Alternative Name: ADAMTSL1

Background: Punctin-1 is a secreted molecule resembling members of the family of proteases designated ADAMTS (a disintegrin-like and metalloprotease domain with thrombospondin type I motif). ADAMTS proteases are secreted enzymes that consist of a metalloprotease domain (which provides the catalytic activity) and ancillary domains (which provide substrate, cell or extracellular matrix activity). Punctin-1 lacks the pro-metalloprotease and the disintegrin-like domain typical of this family but contains other ADAMTS domains in precise order including 4 thrombospondin-I repeats. Punctin-1 is an extracellular matrix protein in tissues and deposited into the cell substratum and localized towards the periphery of transfected cells. Punctin-1 and Punctin-2 (ADAMTSL-3) are the first members of a novel family of ADAMTS-like proteins that appear to have important functions in the extracellular matrix.Synonyms: ADAMTS-like protein 1, ADAMTSL-1, ADAMTSR1

Gene ID: 92949

NCBI Accession: NP_001035362

UniProt: Q8N6G6