SNCA antibody (AA 1-140)

Catalog No. ABIN1105339

This Mouse Monoclonal antibody specifically detects SNCA in WB. It exhibits reactivity toward Human.

Quick Overview for SNCA antibody (AA 1-140) (ABIN1105339)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 4C1

Product Details anti-SNCA Antibody

Binding Specificity: AA 1-140

Specificity: This antibody recognizes the recombinant α-synuclein.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G affinity purified

Immunogen: Recombinant human alpha-synuclein (1-140 aa) expressed in E. coli.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Double distillated water is recommended to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20 °C.

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha-Synuclein / SNCA

Background: Alpha-Synuclein belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. Alpha-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble Aβ into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and is also observed in senile plaques of Alzheimer's disease patients. Human α-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1

Gene ID: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity