beta 2 Adrenergic Receptor antibody

Catalog No. ABIN1105514

The Mouse Monoclonal anti-beta 2 Adrenergic Receptor antibody has been validated for EIA, Func and ELISA (Detection). It is suitable to detect beta 2 Adrenergic Receptor in samples from Human, Rat and Guinea Pig.

Quick Overview for beta 2 Adrenergic Receptor antibody (ABIN1105514)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reactivity: Human, Rat, Guinea Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Functional Studies (Func), ELISA (Detection)

Clone: 6H8

Product Details anti-beta 2 Adrenergic Receptor Antibody

Specificity: The monoclonal antibody 6H8 recognizes Human beta-2-Adrenoceptor.

Cross-Reactivity (Details): Species reactivity (tested):Human, Rat, Guinea Pig.

Purification: Protein G

Immunogen: Free peptide Beta2-H19C

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: beta-2 Adrenergic Receptor

Background: The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.Synonyms: ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

Gene ID: 154

NCBI Accession: NP_000015

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation