BPDE-DNA antibody

Catalog No. ABIN1105553

The Mouse Monoclonal anti-BPDE-DNA antibody is suitable to detect BPDE-DNA in samples from Mammalian. It has been validated for IF, IHC (p), IP and EIA.

Quick Overview for BPDE-DNA antibody (ABIN1105553)

Target: BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))

Reactivity: Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This BPDE-DNA antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Clone: 5D11

Product Details anti-BPDE-DNA Antibody

Purification: Protein G

Immunogen: BPDE-I-DNA complexed with methylated BSA

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for BPDE-DNA

Target: BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))

Alternative Name: BPDE-DNA

Background: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representative PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.