Verified
CX3CR1
Reactivity: Human
WB, ELISA
Host: Goat
Polyclonal
unconjugated
Restrictions
For Research Use only
Format
Lyophilized
Storage
4 °C
Szukiewicz, Kochanowski, Mittal, Pyzlak, Szewczyk, Cendrowski: "CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 63, Issue 3, pp. 179-89, (2014) (PubMed).
Fractalkine, also termed neurotactin, is a membrane-bound CX3C chemokine1. Human CX3CR1, also named V28, was first cloned from human genomic DNA libraries2. A G-protein-coupled seven-transmembrane domain receptor, it was recently identified to serve as fractalkine receptor3 ,4. Human CX3CR1 has been shown to mediate both the adhesive and migratory functions of fractalkine. Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators.