CXCR4 antibody

Catalog No. ABIN110595

Cited in 5+ publications. The Rabbit Polyclonal anti-CXCR4 antibody (ABIN110595) specifically detects CXCR4 in WB, FACS and Neut. The antibody is reactive with Mouse and Rat samples.

Quick Overview for CXCR4 antibody (ABIN110595)

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Neutralization (Neut)

Product Details anti-CXCR4 Antibody

Specificity: Cross-reactivity to CXCR4 of other species has not been determined.

Immunogen: This polyclonal antibody, which reacts with both rat and mouse CXCR4, was generated using E. coli-expressed rat CXCR4 as an immunogen.

Application Details

Application Notes: The tested titer for Western blot is 1:2,000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: 4 °C

References for anti-CXCR4 antibody (ABIN110595)

Chen, Chemaly, Liang, Kho, Lee, Park, Altman, Schecter, Hajjar, Tarzami: "Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1705-15, (2010) (PubMed).

Neusser, Lindenmeyer, Moll, Segerer, Edenhofer, Sen, Stiehl, Kretzler, Gröne, Schlöndorff, Cohen: "Human nephrosclerosis triggers a hypoxia-related glomerulopathy." in: The American journal of pathology, Vol. 176, Issue 2, pp. 594-607, (2010) (PubMed).

Kioi, Vogel, Schultz, Hoffman, Harsh, Brown: "Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice." in: The Journal of clinical investigation, Vol. 120, Issue 3, pp. 694-705, (2010) (PubMed).

Shyu, Lin, Yang, Tzeng, Pang, Yen, Li: "Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells." in: Circulation, Vol. 110, Issue 13, pp. 1847-54, (2004) (PubMed).

Petit, Szyper-Kravitz, Nagler, Lahav, Peled, Habler, Ponomaryov, Taichman, Arenzana-Seisdedos, Fujii, Sandbank, Zipori, Lapidot: "G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4." in: Nature immunology, Vol. 3, Issue 7, pp. 687-94, (2002) (PubMed).

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4

Background: CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor for HIV?s binding to CD4 through envelope glycoprotein gp 1202. In other cases, CXCR4 can even function as the only receptor for HIV-2?s binding to the CD4 ? host cells3. Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events