CD37 antibody

Catalog No. ABIN1106328

The Mouse Monoclonal anti-CD37 antibody (Clone IPO-24) (ABIN1106328) specifically detects CD37 in IHC (p), IHC (fro) and EIA. The antibody is reactive with Human samples.

Quick Overview for CD37 antibody (ABIN1106328)

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD37 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: IPO-24

Product Details anti-CD37 Antibody

Specificity: This antibody reacts with CD37 antigen (Human), 40-52 kDa glycoprotein. IPO-24 reacts with Human B cell lines Daudi, Raji, Namalva, Ramos and CABIL, whereas T cell lines CEM, Molt-4, Jurkat, MT-4, H9 and non-lymphoid cell lines MeWo and A-431 are not labelled. IPO-24 stains B cell follicles and the most strongly labelled elements are mantle zone lymphoid cells. Neutrofils, macrophages, thymocytes and dendritic reticulum cells are negative.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogen: IPO-24 was generated after immunization of BALB/c mice with spleen cells of a patient with hairy cell leukemia. Mice splenocytes were fused with the P3-X63-Ag8.653 mouse myeloma cell line.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CD37

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Alternative Name: CD37

Background: CD37 is a membrane protein of the tetraspanin superfamily, which includes CD9, CD53, CD81, and the R2 antigen among others. Many of these molecules are expressed on leukocytes and have been implicated in signal transduction, cell to cell interactions, and cellular activation and development. The antigen CD37 defined by IPO-24 is B lineage restricted and is strongly expressed throughout B cell ontogeny from pre-B cells untill the plasmoblasts. CD37 is an extensively glycosylated molecule and usually two and sometimes three N-linked carbohydrate chain are attached to the protein. Synonyms: Leukocyte antigen CD37, TSPAN26, Tetraspanin-26

Gene ID: 951

NCBI Accession: NP_001765

UniProt: P11049

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response