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Collagen Type V antibody

This Mouse Monoclonal antibody specifically detects Collagen Type V in IHC (fro), EIA and RIA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.
Catalog No. ABIN1106758

Quick Overview for Collagen Type V antibody (ABIN1106758)

Target

See all Collagen Type V (COL5) Antibodies
Collagen Type V (COL5) (Collagen, Type V (COL5))

Reactivity

  • 24
  • 7
  • 5
  • 4
  • 2
  • 2
  • 1
Human

Host

  • 16
  • 9
  • 5
Mouse

Clonality

  • 25
  • 5
Monoclonal

Conjugate

  • 23
  • 5
  • 1
  • 1
This Collagen Type V antibody is un-conjugated

Application

  • 22
  • 21
  • 16
  • 10
  • 9
  • 7
  • 7
  • 6
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Clone

MC5-HA
  • Specificity

    The antibody reacts with native Human as well as heat denatured Human Collagen type V in RIA, ELISA and immunoblot assays. The antibody does not react with Collagen types I, II, III and IV. Human plasma proteins do not interfere with binding to collagen.

    Cross-Reactivity (Details)

    Species reactivity (tested):Human.

    Purification

    PEG6000 precipitation + Sepharose 6B gel filtration

    Isotype

    IgM
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Reconstitution

    Restore with 1 mL sterile water. Add preservative if preferred.

    Storage

    4 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C.
  • Rukosuev, Nanaev, Milovanov: "Participation of collagen types I, III, IV, V, and fibronectin in the formation of villi fibrosis in human term placenta." in: Acta histochemica, Vol. 89, Issue 1, pp. 11-6, (1991) (PubMed).

  • Target

    Collagen Type V (COL5) (Collagen, Type V (COL5))

    Alternative Name

    Collagen Type V

    Background

    Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. Type V Collagen is a member of group I Collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V Collagen binds to DNA, heparan sulfate, Thrombospondin, Heparin, and Insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI Collagen and it is possible that the Collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.Synonyms: COL5A1

    Gene ID

    1289

    NCBI Accession

    NP_000084

    UniProt

    P20908
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