C5 antibody

Catalog No. ABIN1106794

This Rabbit Polyclonal antibody specifically detects C5 in WB. It exhibits reactivity toward Mouse.

Quick Overview for C5 antibody (ABIN1106794)

Target: C5 (Complement Component 5 (C5))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-C5 Antibody

Specificity: This antibody detects C5.

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Purification: Protein A

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: Complement C5

Background: C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5 into C5a and C5b. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8. C5b initiates the assembly of the membrane attack complex (MAC) that mediates cytolysis.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4, Complement component 5

Gene ID: 15139

NCBI Accession: NP_034536

UniProt: P06684

Pathways: Complement System, Carbohydrate Homeostasis