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C5 antibody (AA 1-77)

C5 Reactivity: Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043765
  • Target See all C5 Antibodies
    C5 (Complement Component 5 (C5))
    Binding Specificity
    • 23
    • 15
    • 15
    • 15
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-77
    Reactivity
    • 124
    • 32
    • 18
    • 16
    • 2
    • 2
    • 2
    Rat
    Host
    • 112
    • 15
    • 6
    • 4
    Rabbit
    Clonality
    • 122
    • 14
    Polyclonal
    Conjugate
    • 48
    • 13
    • 12
    • 9
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    This C5 antibody is un-conjugated
    Application
    • 68
    • 50
    • 42
    • 39
    • 26
    • 19
    • 12
    • 9
    • 7
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Complement C5(C5) detection. Tested with WB, IHC-P in Rat.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Complement C5(C5) detection. Tested with WB, IHC-P in Rat.
    Gene Name: complement component 5
    Protein Name: Complement C5
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived rat C5a recombinant protein (Position: D1-R77). Rat C5a shares 62% and 82% amino acid (aa) sequences identity with human and mouse C5a, respectively.
    Isotype
    IgG
    Top Product
    Discover our top product C5 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, The detection limit for C5a is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    C5 (Complement Component 5 (C5))
    Alternative Name
    C5 (C5 Products)
    Synonyms
    C5 antibody, LOC565774 antibody, C5a antibody, C5b antibody, CPAMD4 antibody, Hc antibody, RGD1561905 antibody, He antibody, complement C5 antibody, complement component 5 antibody, hemolytic complement antibody, C5 antibody, c5 antibody, Hc antibody
    Background
    C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. C5a plays a key role in increasing migration and adherence of neutrophils and monocytes to vessel walls. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to susceptibility to liver fibrosis and to rheumatoid arthritis.

    Synonyms: Anaphylatoxin C5a analog antibody|Anaphylatoxin C5a antibody|C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody|C5 antibody|C5a antibody|CO5_HUMAN antibody|Complement C5 alpha'' chain antibody|Complement C5 antibody|Complement component C5 antibody|Complement component C5a antibody|CPAMD 4 antibody|CPAMD4 antibody
    Gene ID
    362119
    UniProt
    P08650
    Pathways
    Complement System, Carbohydrate Homeostasis
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