Corneodesmosin antibody

Catalog No. ABIN1106821

This Rabbit Polyclonal antibody specifically detects Corneodesmosin in WB, EIA and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for Corneodesmosin antibody (ABIN1106821)

Target: Corneodesmosin (CDSN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Corneodesmosin antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Corneodesmosin Antibody

Specificity: This antibody reacts with Human 51 kDa CDSN protein. May cross react with proteins from other species.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from N-termiknal domain of Human CDSN.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Corneodesmosin

Target: Corneodesmosin (CDSN)

Alternative Name: Corneodesmosin / CDSN

Background: Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520], also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade. Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300], also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.Synonyms: S protein

Gene ID: 1041

NCBI Accession: NP_001255