Desmin antibody

Catalog No. ABIN1106975

The Mouse Monoclonal anti-Desmin antibody has been validated for WB, IF and IHC (fro). It is suitable to detect Desmin in samples from Human, Rat, Mouse, Chicken, Hamster, Pig, Dog, Rabbit and Zebrafish (Danio rerio).

Quick Overview for Desmin antibody (ABIN1106975)

Target: Desmin (DES)

Reactivity: Human, Rat, Mouse, Chicken, Hamster, Pig, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: RD301

Product Details anti-Desmin Antibody

Purification: Purified

Immunogen: Cytoskeletal desmin extract of chicken gizzard.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS with 0.09 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the lyophilized antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. store the reconstituted antibody at -20 °C.

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: Desmin

Background: Desmin (53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.Synonyms: DES

Gene ID: 9031

UniProt: P02542