HES1 antibody (C-Term)

Catalog No. ABIN1107521

The Rabbit Polyclonal anti-HES1 antibody has been validated for WB, IHC (fro) and EIA. It is suitable to detect HES1 in samples from Mouse.

Quick Overview for HES1 antibody (C-Term) (ABIN1107521)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Product Details anti-HES1 Antibody

Binding Specificity: C-Term

Specificity: Reacts with Mouse 30 kDa Hes1 protein. Cross reacts with Rat and Human.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from C-terminal domain of HES-1 protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Target Details for HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Alternative Name: HES1

Background: HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like

Gene ID: 15205

NCBI Accession: NP_032261

Pathways: DNA Damage Repair