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IL27 antibody

IL27 Reactivity: Human FACS Host: Mouse Monoclonal B-G49 unconjugated
Catalog No. ABIN1107834
  • Target See all IL27 Antibodies
    IL27 (Interleukin-27 Subunit alpha (IL27))
    Reactivity
    • 16
    • 14
    • 10
    Human
    Host
    • 16
    • 3
    Mouse
    Clonality
    • 16
    • 3
    Monoclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL27 antibody is un-conjugated
    Application
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Flow Cytometry (FACS)
    Specificity
    Recognizes both natural and recombinant Human IL-27
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Ion Exchange Chromatography.
    Sterility
    0.22 μm filtered
    Immunogen
    Recombinant Human IL-27.
    Clone
    B-G49
    Isotype
    IgG2a
    Top Product
    Discover our top product IL27 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    IL27 (Interleukin-27 Subunit alpha (IL27))
    Alternative Name
    Interleukin-27 / IL27A (IL27 Products)
    Synonyms
    IL-27 antibody, IL-27A antibody, IL27A antibody, IL27p28 antibody, IL30 antibody, p28 antibody, EUROIMAGE1875335 antibody, IL25 antibody, IL27 antibody, IL27w antibody, R33729_1 antibody, SF20 antibody, IL-27p28 antibody, Il30 antibody, interleukin 27 antibody, myeloid derived growth factor antibody, IL27 antibody, MYDGF antibody, Il27 antibody
    Background
    Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28
    Gene ID
    246778
    NCBI Accession
    NP_663634
    UniProt
    Q8NEV9
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