IL27 antibody

Catalog No. ABIN1107836

The Mouse Monoclonal anti-IL27 antibody is suitable to detect IL27 in samples from Human. It has been validated for FACS.

Quick Overview for IL27 antibody (ABIN1107836)

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL27 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: B-G49

Product Details anti-IL27 Antibody

Specificity: Recognizes both natural and recombinant Human IL-27

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ion Exchange Chromatography.

Immunogen: Recombinant Human IL-27.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IL27

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Alternative Name: Interleukin-27 / IL27A

Background: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28

Gene ID: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9