Lipoteichoic Acid antibody

Catalog No. ABIN1108055

Product Details anti-Lipoteichoic Acid Antibody

Target: Lipoteichoic Acid (LTA)

Reactivity: Please inquire

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lipoteichoic Acid antibody is un-conjugated

Application: Immunofluorescence (IF), Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Endotoxin Level: Low Endotoxin

Immunogen: Microbial mixture of Streptococcus sobrims HG961, HG962, HG970, and HG977

Clone: 55

Isotype: IgG3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

References for anti-Lipoteichoic Acid antibody (ABIN1108055)

Droeser, Hirt, Viehl, Frey, Nebiker, Huber, Zlobec, Eppenberger-Castori, Tzankov, Rosso, Zuber, Muraro, Amicarella, Cremonesi, Heberer, Iezzi, Lugli, Terracciano, Sconocchia, Oertli, Spagnoli et al.: "Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. ..." in: European journal of cancer (Oxford, England : 1990), Vol. 49, Issue 9, pp. 2233-42, (2014) (PubMed).

Hirose, Murosaki, Fujiki, Yamamoto, Yoshikai, Yamashita: "Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production." in: Microbiology and immunology, Vol. 54, Issue 3, pp. 143-51, (2010) (PubMed).

Hashimoto, Tabuchi, Sakurai, Kutsuna, Kurokawa, Awasaki, Sekimizu, Nakanishi, Shiratsuchi: "Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7451-60, (2009) (PubMed).

Jimenez-Dalmaroni, Xiao, Corper, Verdino, Ainge, Larsen, Painter, Rudd, Dwek, Hoebe, Beutler, Wilson: "Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2." in: PLoS ONE, Vol. 4, Issue 10, pp. e7411, (2009) (PubMed).

Yajima, Takahashi, Shimazu, Urano-Tashiro, Uchikawa, Karibe, Konishi: "Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing." in: FEMS microbiology letters, Vol. 297, Issue 2, pp. 196-202, (2009) (PubMed).

Gründling, Schneewind: "Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 20, pp. 8478-83, (2007) (PubMed).

Henneke, Morath, Uematsu, Weichert, Pfitzenmaier, Takeuchi, Müller, Poyart, Akira, Berner, Teti, Geyer, Hartung, Trieu-Cuot, Kasper, Golenbock: "Role of lipoteichoic acid in the phagocyte response to group B streptococcus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 10, pp. 6449-55, (2005) (PubMed).

Triantafilou, Manukyan, Mackie, Morath, Hartung, Heine, Triantafilou: "Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40882-9, (2004) (PubMed).

van Langevelde, Ravensbergen, Grashoff, Beekhuizen, Groeneveld, van Dissel: "Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes." in: Antimicrobial agents and chemotherapy, Vol. 43, Issue 12, pp. 2984-9, (2000) (PubMed).

van Langevelde, van Dissel, Ravensbergen, Appelmelk, Schrijver, Groeneveld: "Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: quantitative measurements and biological reactivities." in: Antimicrobial agents and chemotherapy, Vol. 42, Issue 12, pp. 3073-8, (1999) (PubMed).

Target Details for Lipoteichoic Acid

Target: Lipoteichoic Acid (LTA)

Abstract: LTA Products

Synonyms: LT antibody, TNFB antibody, TNFSF1 antibody, lymphotoxin alpha antibody, LTA antibody

Target Type: Chemical

Background: LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2. Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface.