MBP/MBL antibody

Catalog No. ABIN1108116

This anti-MBP/MBL antibody is a Rat Monoclonal antibody detecting MBP/MBL in WB and EIA. Suitable for Mouse.

Quick Overview for MBP/MBL antibody (ABIN1108116)

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This MBP/MBL antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 16A8

Product Details anti-MBP/MBL Antibody

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Purification: Protein G

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for MBP/MBL

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Alternative Name: Mannan Binding Protein

Background: Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C

Gene ID: 10090

UniProt: P41317