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Mbl1 antibody

Mbl1 Reactivity: Mouse WB, IF, EIA, IHC (fro) Host: Rat Monoclonal 8G6 unconjugated
Catalog No. ABIN1108168
  • Target See all Mbl1 Antibodies
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Reactivity
    Mouse
    Host
    • 2
    • 1
    • 1
    Rat
    Clonality
    • 2
    • 2
    Monoclonal
    Conjugate
    • 4
    This Mbl1 antibody is un-conjugated
    Application
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein G
    Immunogen
    Purified mouse MBL-A
    Clone
    8G6
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Target
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Alternative Name
    MBL-A (Mbl1 Products)
    Synonyms
    MBL-A antibody, MBP-A antibody, pMBP-28 antibody, S-MBP antibody, Mbpa antibody, Mlb1 antibody, mannan-binding lectin (A) antibody, mannose-binding lectin (protein A) 1 antibody, MBL1 antibody, Mbl1 antibody
    Background
    Mannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity. In human, MBL is encoded by a single gene, whereas in mice there are two homologous proteins, termed MBL-A and MBL-C. The MBL-A concentration in serum is about 6-fold lower compared to that of MBL-C... MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. Moreover, it has been shown that MBL-A deficient mice have aberrant antigen-specific IgM responses and suffer from increased susceptibility to infection.
    Gene ID
    17194
    NCBI Accession
    NP_034905
    UniProt
    P39039
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