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MHC Class II Antigen I Ak,d,b,q,r antibody

Reactivity: Mouse, Human FACS, IHC (fro) Host: Rat Monoclonal ER-TR3 unconjugated
Catalog No. ABIN1108234
  • Target
    MHC Class II Antigen I Ak,d,b,q,r
    Reactivity
    Mouse, Human
    Host
    • 4
    Rat
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 2
    • 1
    • 1
    Un-conjugated
    Application
    • 4
    • 4
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse, human (tonsil)
    Purification
    Protein G
    Clone
    ER-TR3
    Isotype
    IgG2b
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at < -20 °C for at least 6 months.
    Expiry Date
    6 months
  • Target
    MHC Class II Antigen I Ak,d,b,q,r
    Alternative Name
    MHC Class II (I-A K,b,d,q,r)
    Background
    MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen-presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they acquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC Class II.
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