NPY1R antibody (C-Term)

Catalog No. ABIN1108431

The Rabbit Polyclonal anti-NPY1R antibody (ABIN1108431) specifically detects NPY1R in WB and IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for NPY1R antibody (C-Term) (ABIN1108431)

Target: NPY1R (Neuropeptide Y Receptor 1 (NPY1R))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPY1R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NPY1R Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Neuropeptide Y receptor 1 (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide mapping at the C-terminal of human NPY1R .Remarks: Sequence is identical to the related rat and mouse sequence.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for NPY1R

Target: NPY1R (Neuropeptide Y Receptor 1 (NPY1R))

Alternative Name: Neuropeptide Y Receptor 1

Background: Neuropeptide Y Receptor Y1 (NPY1R) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiological activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system.. Two major subtypes of NPY receptor (Y1 and Y2) have been defined by pharmacological criteria. NPY1R and NPY2R encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. NPY1R is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.Synonyms: NPYR, NPYY1, Neuropeptide Y receptor 1

Gene ID: 4886

NCBI Accession: NP_000900

UniProt: P25929

Pathways: Feeding Behaviour