Occludin antibody (AA 358-504)

Catalog No. ABIN1108503

This anti-Occludin antibody is a Guinea Pig Polyclonal antibody detecting Occludin in WB, IF and IHC (fro). Suitable for Human, Mouse, Rat and Dog. This Primary Antibody has been cited in 1 publication.

Quick Overview for Occludin antibody (AA 358-504) (ABIN1108503)

Target: Occludin (OCLN)

Reactivity: Human, Mouse, Rat, Dog

Host: Guinea Pig

Clonality: Polyclonal

Conjugate: This Occludin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Occludin Antibody

Binding Specificity: AA 358-504

Specificity: The polyclonal antibody reacts with Occludin.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat, Canine.

Purification: Protein A Chromatography

Immunogen: Recombinant Human Occludin (aa 358-504)

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

References for anti-Occludin antibody (ABIN1108503)

Liu, Gu, Zhu, Yuan, Zhu, Zhu, Yao, Hu, Zhang, Dicksved, Bao, Cai: "Epithelial Heat Shock Proteins Mediate the Protective Effects of Limosilactobacillus reuteri in Dextran Sulfate Sodium-Induced Colitis." in: Frontiers in immunology, Vol. 13, pp. 865982, (2022) (PubMed).

Target Details for Occludin

Target: Occludin (OCLN)

Alternative Name: Occludin

Background: Occludin is an integral membrane protein specifically associated with tight junctions. These specialized regions of the plasma membrane prevent the diffusion of dissolved molecules between adjacent epithelial cells, seal off body cavities such as intestine or stomach lumen and prevent the diffusion of membrane proteins and glycolipids between the apical and basolateral regions of the plasma membrane. Occludin is localized at tight junctions of both epithelial and endothelial cells and is highly expressed in kidney and has not been detected in testis. On the cytoplasmic surface of occludin, a domain within the C-terminal 150 residues has been shown to bind directly to the well-characterized tight junction protein zona occludens 1 (ZO-1).Synonyms: OCLN

Gene ID: 100506658

NCBI Accession: NP_001192183

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C